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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CPSF1 All Species: 28.48
Human Site: Y797 Identified Species: 52.22
UniProt: Q10570 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q10570 NP_037423.2 1443 160884 Y797 E N G T M E I Y Q L P D W R L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532356 1499 165986 Y853 E N G T M E I Y Q L P D W R L
Cat Felis silvestris
Mouse Mus musculus Q9EPU4 1441 160800 Y795 E N G T M E I Y Q L P D W R L
Rat Rattus norvegicus NP_001124043 1386 154862 Y791 E N G T M E I Y Q L P D W R L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514888 831 91833 K247 Q E P P V K K K R V E Q A L S
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001108153 1449 162918 Y803 E N G V M E I Y Q L P D W R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9V726 1455 164663 Y806 Q S G T L E I Y S M P D M K L
Honey Bee Apis mellifera XP_624382 1415 160872 Y783 D S G T L E I Y S L P D L R L
Nematode Worm Caenorhab. elegans Q9N4C2 1454 162698 H788 E N G R L S I H S L P E M E V
Sea Urchin Strong. purpuratus XP_789715 1220 135970 D636 Y M L A L V E D D I M I Y E A
Poplar Tree Populus trichocarpa XP_002318462 1455 159431 A837 K G V K E E V A G A G R K E S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FGR0 1442 158057 I820 R H L S D M P I H E L E Y E L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SEY2 1456 158155 Y807 T S G V L Y I Y R L P D L T K
Conservation
Percent
Protein Identity: 100 N.A. N.A. 90.8 N.A. 96.5 92.8 N.A. 50.6 N.A. N.A. 79.6 N.A. 46.7 54.3 31.5 47.6
Protein Similarity: 100 N.A. N.A. 92.5 N.A. 98 94.3 N.A. 53.3 N.A. N.A. 89.2 N.A. 65.5 71 52.2 60.7
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 0 N.A. N.A. 93.3 N.A. 53.3 66.6 40 0
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 100 N.A. 33.3 N.A. N.A. 93.3 N.A. 86.6 86.6 66.6 20
Percent
Protein Identity: 33.1 N.A. N.A. 32.8 N.A. 28
Protein Similarity: 51.6 N.A. N.A. 51.8 N.A. 48.7
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. 40
P-Site Similarity: 20 N.A. N.A. 33.3 N.A. 60
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 0 0 0 8 0 8 0 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 0 8 0 0 8 8 0 0 62 0 0 0 % D
% Glu: 47 8 0 0 8 62 8 0 0 8 8 16 0 31 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 70 0 0 0 0 0 8 0 8 0 0 0 0 % G
% His: 0 8 0 0 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 70 8 0 8 0 8 0 0 0 % I
% Lys: 8 0 0 8 0 8 8 8 0 0 0 0 8 8 8 % K
% Leu: 0 0 16 0 39 0 0 0 0 62 8 0 16 8 62 % L
% Met: 0 8 0 0 39 8 0 0 0 8 8 0 16 0 0 % M
% Asn: 0 47 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 8 8 0 0 8 0 0 0 70 0 0 0 0 % P
% Gln: 16 0 0 0 0 0 0 0 39 0 0 8 0 0 0 % Q
% Arg: 8 0 0 8 0 0 0 0 16 0 0 8 0 47 0 % R
% Ser: 0 24 0 8 0 8 0 0 24 0 0 0 0 0 16 % S
% Thr: 8 0 0 47 0 0 0 0 0 0 0 0 0 8 0 % T
% Val: 0 0 8 16 8 8 8 0 0 8 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 39 0 0 % W
% Tyr: 8 0 0 0 0 8 0 62 0 0 0 0 16 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _