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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCAP All Species: 11.21
Human Site: S677 Identified Species: 24.67
UniProt: Q12770 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12770 NP_036367.2 1279 139729 S677 R H P Q D G R S A W P P P G P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001100342 1223 133661 A645 S Y Y N I T L A K R Y I S L L
Dog Lupus familis XP_541898 1261 137697 S677 R H P Q D G R S A W P Q R R P
Cat Felis silvestris
Mouse Mus musculus Q6GQT6 1276 139592 S677 R H P Q D G R S A W A P Q E P
Rat Rattus norvegicus A2RRU4 1276 139480 T677 R H P Q D G R T A W A P P E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001231540 1275 140135 R677 R H P Q E A N R Y H P F L S S
Frog Xenopus laevis A0JPH4 1311 145343 H687 R H P Q E A Q H S H P Y L Q R
Zebra Danio Brachydanio rerio XP_686585 1245 136420 H664 R H P Q D T Q H A P P P P P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_788277 1276 142477 F695 S A P S G S G F S T P I K A P
Honey Bee Apis mellifera XP_394934 1329 150443 F672 Q H F Q W Q S F A T A A L D P
Nematode Worm Caenorhab. elegans NP_001022051 1087 124644 D520 V Q E P R P E D S V R M K I M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 94 92 N.A. 91.9 92.4 N.A. N.A. 59.1 69.3 68.5 N.A. 29.3 33.1 23 N.A.
Protein Similarity: 100 N.A. 94.5 93.6 N.A. 94.6 95.1 N.A. N.A. 67.6 79.5 77.9 N.A. 47.2 53.7 40.6 N.A.
P-Site Identity: 100 N.A. 0 80 N.A. 80 80 N.A. N.A. 33.3 33.3 60 N.A. 20 26.6 0 N.A.
P-Site Similarity: 100 N.A. 13.3 80 N.A. 80 86.6 N.A. N.A. 40 53.3 66.6 N.A. 26.6 33.3 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 19 0 10 55 0 28 10 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 46 0 0 10 0 0 0 0 0 10 0 % D
% Glu: 0 0 10 0 19 0 10 0 0 0 0 0 0 19 0 % E
% Phe: 0 0 10 0 0 0 0 19 0 0 0 10 0 0 0 % F
% Gly: 0 0 0 0 10 37 10 0 0 0 0 0 0 10 0 % G
% His: 0 73 0 0 0 0 0 19 0 19 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 0 0 19 0 10 0 % I
% Lys: 0 0 0 0 0 0 0 0 10 0 0 0 19 0 0 % K
% Leu: 0 0 0 0 0 0 10 0 0 0 0 0 28 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % M
% Asn: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 73 10 0 10 0 0 0 10 55 37 28 10 55 % P
% Gln: 10 10 0 73 0 10 19 0 0 0 0 10 10 10 0 % Q
% Arg: 64 0 0 0 10 0 37 10 0 10 10 0 10 10 10 % R
% Ser: 19 0 0 10 0 10 10 28 28 0 0 0 10 10 19 % S
% Thr: 0 0 0 0 0 19 0 10 0 19 0 0 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 10 0 0 0 0 37 0 0 0 0 0 % W
% Tyr: 0 10 10 0 0 0 0 0 10 0 10 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _