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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SREBF2
All Species:
13.33
Human Site:
S745
Identified Species:
29.33
UniProt:
Q12772
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12772
NP_004590.2
1141
123688
S745
Y
F
L
S
R
A
Q
S
L
C
G
P
E
H
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001101257
1082
117414
L703
K
T
R
C
G
G
K
L
G
F
L
A
S
Y
F
Dog
Lupus familis
XP_849087
1136
122853
S735
Y
F
L
S
R
A
Q
S
L
C
G
P
E
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3U1N2
1130
122892
S734
Y
F
L
N
R
A
Q
S
L
C
G
P
E
H
S
Rat
Rattus norvegicus
Q3T1I5
1133
122957
S737
Y
F
L
N
R
A
Q
S
L
C
G
P
E
H
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510556
1117
119248
Q721
F
F
L
S
S
A
R
Q
V
C
L
A
Q
S
G
Chicken
Gallus gallus
XP_416222
952
103742
G576
R
W
L
C
H
P
L
G
Q
K
F
F
V
E
R
Frog
Xenopus laevis
Q6GQ26
1088
119806
N701
Y
F
L
G
Y
A
Q
N
A
S
S
E
E
T
L
Zebra Danio
Brachydanio rerio
A3KNA7
1099
120302
A718
Y
L
L
S
C
A
E
A
L
T
C
Q
S
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_730449
1113
124436
Q703
Y
Y
M
S
R
A
R
Q
E
C
G
L
T
R
A
Honey Bee
Apis mellifera
XP_396866
824
93228
L448
Y
L
G
K
A
R
T
L
L
S
S
C
T
V
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
92.7
92.6
N.A.
92.1
92.5
N.A.
45.4
69.4
67.4
50.4
N.A.
29.8
28.4
N.A.
N.A.
Protein Similarity:
100
N.A.
93.1
95.4
N.A.
95.9
96.4
N.A.
59.2
75.4
78.5
65.9
N.A.
47.6
42.8
N.A.
N.A.
P-Site Identity:
100
N.A.
0
93.3
N.A.
93.3
93.3
N.A.
33.3
6.6
40
40
N.A.
40
13.3
N.A.
N.A.
P-Site Similarity:
100
N.A.
13.3
93.3
N.A.
100
100
N.A.
60
13.3
46.6
53.3
N.A.
66.6
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
73
0
10
10
0
0
19
0
0
10
% A
% Cys:
0
0
0
19
10
0
0
0
0
55
10
10
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
0
0
0
0
0
0
10
0
10
0
0
10
46
10
0
% E
% Phe:
10
55
0
0
0
0
0
0
0
10
10
10
0
0
10
% F
% Gly:
0
0
10
10
10
10
0
10
10
0
46
0
0
0
10
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
28
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
0
0
10
0
0
10
0
0
10
0
0
0
0
0
% K
% Leu:
0
19
73
0
0
0
10
19
55
0
19
10
0
0
10
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
19
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
37
0
0
10
% P
% Gln:
0
0
0
0
0
0
46
19
10
0
0
10
10
0
0
% Q
% Arg:
10
0
10
0
46
10
19
0
0
0
0
0
0
19
10
% R
% Ser:
0
0
0
46
10
0
0
37
0
19
19
0
19
10
46
% S
% Thr:
0
10
0
0
0
0
10
0
0
10
0
0
19
10
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
0
0
10
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
73
10
0
0
10
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _