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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF5
All Species:
5.15
Human Site:
S950
Identified Species:
12.59
UniProt:
Q12774
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12774
NP_005426.2
1597
176799
S950
P
E
L
Q
G
P
T
S
K
D
E
A
G
V
S
Chimpanzee
Pan troglodytes
XP_519460
1754
193086
S1107
P
E
L
Q
G
P
T
S
K
D
E
A
G
V
S
Rhesus Macaque
Macaca mulatta
XP_001094223
1859
204116
P1212
P
E
L
Q
G
S
T
P
K
D
E
A
G
V
S
Dog
Lupus familis
XP_539834
1604
174905
P957
W
S
L
E
L
Q
G
P
T
C
E
P
G
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BWA8
802
88833
G185
L
S
G
N
A
R
G
G
L
E
A
P
E
R
R
Rat
Rattus norvegicus
XP_001073085
1589
177312
T942
S
P
E
L
Q
I
P
T
S
K
D
E
S
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518302
453
52163
Chicken
Gallus gallus
XP_417225
1733
193947
G1077
E
Q
R
T
N
L
F
G
V
D
T
K
N
I
R
Frog
Xenopus laevis
NP_001128552
856
97785
N238
L
Q
L
T
Q
R
R
N
N
F
T
A
R
L
G
Zebra Danio
Brachydanio rerio
XP_697662
977
110044
K360
R
K
N
S
F
T
L
K
L
G
K
S
L
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.5
80
60.1
N.A.
27.1
64.6
N.A.
22.5
35.2
28.4
28.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
88.1
81.9
67.7
N.A.
35.8
72.8
N.A.
25
49.1
38.3
39.8
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
26.6
N.A.
0
0
N.A.
0
6.6
13.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
33.3
N.A.
6.6
13.3
N.A.
0
20
33.3
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
0
0
0
10
40
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
40
10
0
0
0
0
% D
% Glu:
10
30
10
10
0
0
0
0
0
10
40
10
10
0
0
% E
% Phe:
0
0
0
0
10
0
10
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
10
0
30
0
20
20
0
10
0
0
40
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
10
0
0
0
0
0
10
30
10
10
10
0
0
0
% K
% Leu:
20
0
50
10
10
10
10
0
20
0
0
0
10
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
10
0
0
10
10
0
0
0
10
0
0
% N
% Pro:
30
10
0
0
0
20
10
20
0
0
0
20
0
10
0
% P
% Gln:
0
20
0
30
20
10
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
10
0
0
20
10
0
0
0
0
0
10
10
20
% R
% Ser:
10
20
0
10
0
10
0
20
10
0
0
10
10
10
40
% S
% Thr:
0
0
0
20
0
10
30
10
10
0
20
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
10
0
0
0
0
30
0
% V
% Trp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _