Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC20 All Species: 28.48
Human Site: S12 Identified Species: 44.76
UniProt: Q12834 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12834 NP_001246.2 499 54723 S12 A F E S D L H S L L Q L D A P
Chimpanzee Pan troglodytes XP_513374 499 54758 S12 A F E S D L H S L L Q L D A P
Rhesus Macaque Macaca mulatta XP_001090604 457 50182 A10 A A N R S H S A G R T P G R T
Dog Lupus familis XP_539651 499 54777 S12 V F E S D L H S L L Q L D A P
Cat Felis silvestris
Mouse Mus musculus Q9JJ66 499 54797 S12 V F E S D L H S L L Q L D A P
Rat Rattus norvegicus Q62623 499 54810 S12 V F E S D L H S L L Q L D A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006536 507 56149 G12 V F E A D L H G L L K L D T P
Frog Xenopus laevis NP_001079443 506 56086 S12 A F E T D I N S I L K L D T P
Zebra Danio Brachydanio rerio NP_998245 496 54922 N12 G F E N D I H N V L R L D M P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477501 526 57062 N12 N F V S D L Q N A L I M D G E
Honey Bee Apis mellifera XP_624567 512 57052 N12 K Y M K E I N N L T R M D E T
Nematode Worm Caenorhab. elegans Q09373 507 56366 T25 S A Q Q N G L T M R K R D M T
Sea Urchin Strong. purpuratus XP_781780 524 57779 T12 Y S E I E K L T K L D G P T G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L3Z8 483 52822 S18 V I T N S N S S S M R N L S P
Baker's Yeast Sacchar. cerevisiae P53197 566 62803 S42 S S A S L L S S P S R R S R P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 91.3 97.5 N.A. 94.7 94.9 N.A. N.A. 80 75 60.5 N.A. 51.3 50.9 24 58.9
Protein Similarity: 100 98.8 91.5 98.4 N.A. 96.9 96.9 N.A. N.A. 89.9 89.1 76.7 N.A. 66.3 68.9 44.7 74.6
P-Site Identity: 100 100 6.6 93.3 N.A. 93.3 93.3 N.A. N.A. 66.6 60 53.3 N.A. 40 13.3 6.6 13.3
P-Site Similarity: 100 100 13.3 93.3 N.A. 93.3 93.3 N.A. N.A. 80 93.3 86.6 N.A. 53.3 60 46.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 35.2 33.7 N.A.
Protein Similarity: N.A. N.A. N.A. 52.3 52.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 27 14 7 7 0 0 0 7 7 0 0 0 0 34 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 60 0 0 0 0 0 7 0 74 0 0 % D
% Glu: 0 0 60 0 14 0 0 0 0 0 0 0 0 7 7 % E
% Phe: 0 60 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 0 0 7 0 7 7 0 0 7 7 7 7 % G
% His: 0 0 0 0 0 7 47 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 7 0 20 0 0 7 0 7 0 0 0 0 % I
% Lys: 7 0 0 7 0 7 0 0 7 0 20 0 0 0 0 % K
% Leu: 0 0 0 0 7 54 14 0 47 67 0 54 7 0 0 % L
% Met: 0 0 7 0 0 0 0 0 7 7 0 14 0 14 0 % M
% Asn: 7 0 7 14 7 7 14 20 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 7 0 0 7 7 0 67 % P
% Gln: 0 0 7 7 0 0 7 0 0 0 34 0 0 0 0 % Q
% Arg: 0 0 0 7 0 0 0 0 0 14 27 14 0 14 0 % R
% Ser: 14 14 0 47 14 0 20 54 7 7 0 0 7 7 0 % S
% Thr: 0 0 7 7 0 0 0 14 0 7 7 0 0 20 20 % T
% Val: 34 0 7 0 0 0 0 0 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _