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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC20 All Species: 33.33
Human Site: S268 Identified Species: 52.38
UniProt: Q12834 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12834 NP_001246.2 499 54723 S268 L R N M T S H S A R V G S L S
Chimpanzee Pan troglodytes XP_513374 499 54758 S268 L R N M T S H S A R V G S L S
Rhesus Macaque Macaca mulatta XP_001090604 457 50182 I238 S L S W N S Y I L S S G S R S
Dog Lupus familis XP_539651 499 54777 S268 L R N M T G H S A R V S S L C
Cat Felis silvestris
Mouse Mus musculus Q9JJ66 499 54797 S268 L R N M T S H S A R V S S L S
Rat Rattus norvegicus Q62623 499 54810 S268 L R N M T S H S A R V S S L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006536 507 56149 S275 L R S M T S H S S R V G S L S
Frog Xenopus laevis NP_001079443 506 56086 S275 L R N M I S H S S R V G A L S
Zebra Danio Brachydanio rerio NP_998245 496 54922 S269 L R S M D G H S A R V G C L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477501 526 57062 S293 L R V M D G H S A R V G S L A
Honey Bee Apis mellifera XP_624567 512 57052 A280 I R V M N G H A A R V G S L S
Nematode Worm Caenorhab. elegans Q09373 507 56366 S271 T L R V G G A S R C A S I A W
Sea Urchin Strong. purpuratus XP_781780 524 57779 A290 L R C M Q G H A A R V G S L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L3Z8 483 52822 R259 T R T M E G H R L R V G A L A
Baker's Yeast Sacchar. cerevisiae P53197 566 62803 I344 I R T L S G H I D R V A C L S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 91.3 97.5 N.A. 94.7 94.9 N.A. N.A. 80 75 60.5 N.A. 51.3 50.9 24 58.9
Protein Similarity: 100 98.8 91.5 98.4 N.A. 96.9 96.9 N.A. N.A. 89.9 89.1 76.7 N.A. 66.3 68.9 44.7 74.6
P-Site Identity: 100 100 26.6 80 N.A. 93.3 93.3 N.A. N.A. 86.6 80 73.3 N.A. 73.3 66.6 6.6 73.3
P-Site Similarity: 100 100 40 80 N.A. 93.3 93.3 N.A. N.A. 100 93.3 80 N.A. 80 80 13.3 80
Percent
Protein Identity: N.A. N.A. N.A. 35.2 33.7 N.A.
Protein Similarity: N.A. N.A. N.A. 52.3 52.1 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 40 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 14 60 0 7 7 14 7 14 % A
% Cys: 0 0 7 0 0 0 0 0 0 7 0 0 14 0 7 % C
% Asp: 0 0 0 0 14 0 0 0 7 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 54 0 0 0 0 0 67 0 0 0 % G
% His: 0 0 0 0 0 0 87 0 0 0 0 0 0 0 0 % H
% Ile: 14 0 0 0 7 0 0 14 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 67 14 0 7 0 0 0 0 14 0 0 0 0 87 0 % L
% Met: 0 0 0 80 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 40 0 14 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 87 7 0 0 0 0 7 7 87 0 0 0 7 0 % R
% Ser: 7 0 20 0 7 47 0 67 14 7 7 27 67 0 74 % S
% Thr: 14 0 14 0 40 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 14 7 0 0 0 0 0 0 87 0 0 0 0 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _