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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDC20 All Species: 47.27
Human Site: S452 Identified Species: 74.29
UniProt: Q12834 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12834 NP_001246.2 499 54723 S452 R V L S L T M S P D G A T V A
Chimpanzee Pan troglodytes XP_513374 499 54758 S452 R V L S L T M S P D G A T V A
Rhesus Macaque Macaca mulatta XP_001090604 457 50182 A417 S P D G A T V A S A A A D E T
Dog Lupus familis XP_539651 499 54777 S452 R V L S L T M S P D G A T V A
Cat Felis silvestris
Mouse Mus musculus Q9JJ66 499 54797 S452 R V L G L T M S P D G A T V A
Rat Rattus norvegicus Q62623 499 54810 S452 R V L S L T M S P D G A T V A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006536 507 56149 S460 R V L N L T M S P D G V T V A
Frog Xenopus laevis NP_001079443 506 56086 S460 R V L N L A M S P D G C T V A
Zebra Danio Brachydanio rerio NP_998245 496 54922 S452 R I L N L A L S P D G S T L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477501 526 57062 S479 R V L Q M A M S P D G S T V I
Honey Bee Apis mellifera XP_624567 512 57052 S466 R V L H L A M S P D G T T I L
Nematode Worm Caenorhab. elegans Q09373 507 56366 V463 N E P I M D L V G S P F D E V
Sea Urchin Strong. purpuratus XP_781780 524 57779 S474 R I L H M A M S P D G T T V V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8L3Z8 483 52822 S439 R V L Y L A V S P D G Q T I V
Baker's Yeast Sacchar. cerevisiae P53197 566 62803 S524 R V L H L T L S N D G T T V V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 91.3 97.5 N.A. 94.7 94.9 N.A. N.A. 80 75 60.5 N.A. 51.3 50.9 24 58.9
Protein Similarity: 100 98.8 91.5 98.4 N.A. 96.9 96.9 N.A. N.A. 89.9 89.1 76.7 N.A. 66.3 68.9 44.7 74.6
P-Site Identity: 100 100 13.3 100 N.A. 93.3 100 N.A. N.A. 86.6 80 60 N.A. 66.6 66.6 0 60
P-Site Similarity: 100 100 26.6 100 N.A. 93.3 100 N.A. N.A. 93.3 86.6 93.3 N.A. 80 73.3 13.3 73.3
Percent
Protein Identity: N.A. N.A. N.A. 35.2 33.7 N.A.
Protein Similarity: N.A. N.A. N.A. 52.3 52.1 N.A.
P-Site Identity: N.A. N.A. N.A. 60 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 73.3 73.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 7 40 0 7 0 7 7 40 0 0 54 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 0 0 7 0 0 7 0 0 0 87 0 0 14 0 0 % D
% Glu: 0 7 0 0 0 0 0 0 0 0 0 0 0 14 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 0 0 0 14 0 0 0 0 7 0 87 0 0 0 0 % G
% His: 0 0 0 20 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 14 0 7 0 0 0 0 0 0 0 0 0 14 7 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 87 0 74 0 20 0 0 0 0 0 0 7 7 % L
% Met: 0 0 0 0 20 0 67 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 20 0 0 0 0 7 0 0 0 0 0 0 % N
% Pro: 0 7 7 0 0 0 0 0 80 0 7 0 0 0 0 % P
% Gln: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 87 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 7 0 0 27 0 0 0 87 7 7 0 14 0 0 0 % S
% Thr: 0 0 0 0 0 54 0 0 0 0 0 20 87 0 7 % T
% Val: 0 74 0 0 0 0 14 7 0 0 0 7 0 67 27 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _