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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: STX4 All Species: 20
Human Site: T72 Identified Species: 36.67
UniProt: Q12846 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12846 NP_004595.2 297 34180 T72 Q Q V T I L A T P L P E E S M
Chimpanzee Pan troglodytes XP_001138080 288 33353 K79 E E L E D L N K E I K K T A N
Rhesus Macaque Macaca mulatta XP_001095454 133 15513
Dog Lupus familis XP_547039 297 34263 T72 Q Q V T I L A T P L P E E S M
Cat Felis silvestris
Mouse Mus musculus P70452 298 34146 T72 Q Q V T I L A T P L P E E S M
Rat Rattus norvegicus Q08850 298 34191 T72 Q Q V T I L A T P L P E E S M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517537 254 29106 I60 I R T Q L K A I E P P K E E E
Chicken Gallus gallus
Frog Xenopus laevis NP_001089849 295 34504 T72 S Q M K V L T T P I P E E N M
Zebra Danio Brachydanio rerio NP_956515 297 33901 V74 K Q K T V L G V A L P E D S M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24547 291 33630 A83 Q E L E D L M A D I K K N A N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O16000 291 33234 R86 E L M A V I K R A A N K V R G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9ZQZ8 305 34465 S86 L R A R M D S S V T E V L K R
Baker's Yeast Sacchar. cerevisiae P39926 295 33715 S73 K D L L T Q V S E E Q E M E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 44.1 44.1 93.9 N.A. 90.2 89.5 N.A. 71 N.A. 52.8 52.5 N.A. 41.4 N.A. 38 N.A.
Protein Similarity: 100 67 44.4 96.9 N.A. 96.3 95.9 N.A. 80.4 N.A. 75.4 75.4 N.A. 63.2 N.A. 60.2 N.A.
P-Site Identity: 100 6.6 0 100 N.A. 100 100 N.A. 20 N.A. 53.3 53.3 N.A. 13.3 N.A. 0 N.A.
P-Site Similarity: 100 46.6 0 100 N.A. 100 100 N.A. 40 N.A. 80 73.3 N.A. 46.6 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 20.3 25.5 N.A.
Protein Similarity: N.A. N.A. N.A. 46.8 51.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 0 39 8 16 8 0 0 0 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 16 8 0 0 8 0 0 0 8 0 0 % D
% Glu: 16 16 0 16 0 0 0 0 24 8 8 54 47 16 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 31 8 0 8 0 24 0 0 0 0 0 % I
% Lys: 16 0 8 8 0 8 8 8 0 0 16 31 0 8 0 % K
% Leu: 8 8 24 8 8 62 0 0 0 39 0 0 8 0 8 % L
% Met: 0 0 16 0 8 0 8 0 0 0 0 0 8 0 47 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 8 0 8 8 16 % N
% Pro: 0 0 0 0 0 0 0 0 39 8 54 0 0 0 0 % P
% Gln: 39 47 0 8 0 8 0 0 0 0 8 0 0 0 0 % Q
% Arg: 0 16 0 8 0 0 0 8 0 0 0 0 0 8 8 % R
% Ser: 8 0 0 0 0 0 8 16 0 0 0 0 0 39 0 % S
% Thr: 0 0 8 39 8 0 8 39 0 8 0 0 8 0 0 % T
% Val: 0 0 31 0 24 0 8 8 8 0 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _