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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
27.88
Human Site:
S13
Identified Species:
51.11
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Chimpanzee
Pan troglodytes
XP_509099
871
93967
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Dog
Lupus familis
XP_857182
860
93116
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Rat
Rattus norvegicus
Q63796
888
96289
S13
E
T
R
T
P
S
P
S
F
G
G
F
V
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
L55
D
M
R
E
K
G
L
L
Q
T
D
L
M
D
N
Frog
Xenopus laevis
A7J1T0
961
107551
S19
E
P
L
N
W
S
S
S
P
N
L
I
V
D
T
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
S13
E
Q
H
A
P
S
P
S
L
S
G
F
T
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
M14
R
G
L
D
T
T
N
M
L
P
I
S
E
E
Q
Honey Bee
Apis mellifera
XP_397605
895
101116
H38
Q
V
V
L
S
P
S
H
P
E
A
H
I
F
T
Nematode Worm
Caenorhab. elegans
O01700
928
103465
E26
E
Q
P
G
P
A
P
E
S
S
D
F
S
T
V
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
T29
A
T
K
D
E
P
I
T
S
Q
H
A
P
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
6.6
33.3
46.6
N.A.
0
6.6
26.6
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
20
33.3
53.3
N.A.
6.6
20
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
8
0
0
0
0
8
8
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
16
0
0
0
0
0
0
16
0
0
16
0
% D
% Glu:
70
0
0
8
8
0
0
8
0
8
0
0
8
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
47
0
0
62
0
8
0
% F
% Gly:
0
8
0
8
0
8
0
0
0
47
54
0
0
0
0
% G
% His:
0
0
8
0
0
0
0
8
0
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
8
8
8
0
0
% I
% Lys:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
16
8
0
0
8
8
16
0
8
8
0
0
0
% L
% Met:
0
8
0
0
0
0
0
8
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
8
0
0
8
0
0
8
0
0
0
0
8
% N
% Pro:
0
8
8
0
62
16
62
0
16
8
0
0
8
0
8
% P
% Gln:
8
16
0
0
0
0
0
0
8
8
0
0
0
0
8
% Q
% Arg:
8
0
54
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
8
62
16
62
16
16
0
8
8
47
0
% S
% Thr:
0
54
0
47
8
8
0
8
0
8
0
0
8
16
62
% T
% Val:
0
8
8
0
0
0
0
0
0
0
0
0
54
0
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _