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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K12 All Species: 36.06
Human Site: S333 Identified Species: 66.11
UniProt: Q12852 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12852 NP_006292.2 859 93219 S333 S L H L P V P S S C P D G F K
Chimpanzee Pan troglodytes XP_509099 871 93967 S366 S L H L P V P S S C P D G F K
Rhesus Macaque Macaca mulatta XP_001105474 890 96134 S366 S L H L P V P S S C P D G F K
Dog Lupus familis XP_857182 860 93116 S333 S L H L P V P S S C P D G F K
Cat Felis silvestris
Mouse Mus musculus Q60700 888 96066 S366 S L H L P V P S S C P D G F K
Rat Rattus norvegicus Q63796 888 96289 S366 S L H L P V P S S C P D G F K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422689 966 107967 S379 S L H L P V P S T C P D G F K
Frog Xenopus laevis A7J1T0 961 107551 S379 S L H L P V P S T C P D G F K
Zebra Danio Brachydanio rerio NP_996977 856 94429 D357 S L Q L P L P D S C P D G F K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95UN8 1161 128942 K368 T L T L P I P K T C P E T W G
Honey Bee Apis mellifera XP_397605 895 101116 A357 S L H L P I P A S C P E G Y R
Nematode Worm Caenorhab. elegans O01700 928 103465 P343 N I L S L P M P E E A P K G L
Sea Urchin Strong. purpuratus XP_795085 943 105022 S354 S L Q L P I P S T C P E G F K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 95.2 97.4 N.A. 92.5 91.7 N.A. N.A. 52.3 51.8 65.4 N.A. 24 38.4 29 38.6
Protein Similarity: 100 95.8 95.6 98.5 N.A. 93.8 93.1 N.A. N.A. 62.5 63.1 74 N.A. 38.4 52.8 44.9 52.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 93.3 80 N.A. 40 66.6 0 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 100 100 86.6 N.A. 73.3 100 13.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 8 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 93 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 0 0 0 70 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 8 0 24 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 77 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 85 8 8 % G
% His: 0 0 70 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 24 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 77 % K
% Leu: 0 93 8 93 8 8 0 0 0 0 0 0 0 0 8 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 93 8 93 8 0 0 93 8 0 0 0 % P
% Gln: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % R
% Ser: 85 0 0 8 0 0 0 70 62 0 0 0 0 0 0 % S
% Thr: 8 0 8 0 0 0 0 0 31 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 62 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _