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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K12 All Species: 16.97
Human Site: S477 Identified Species: 31.11
UniProt: Q12852 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12852 NP_006292.2 859 93219 S477 G L L K P H P S R G L L H G N
Chimpanzee Pan troglodytes XP_509099 871 93967 L491 E L K E R E L L R R E Q A L E
Rhesus Macaque Macaca mulatta XP_001105474 890 96134 S510 G L L K T H P S R G L L H G N
Dog Lupus familis XP_857182 860 93116 S477 G L L K P H P S R S L L H G N
Cat Felis silvestris
Mouse Mus musculus Q60700 888 96066 S510 G L L K S H P S R G L L H G N
Rat Rattus norvegicus Q63796 888 96289 S510 G L L K S H T S R S L L H G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422689 966 107967 V523 G T Y K R H P V R P I I H P N
Frog Xenopus laevis A7J1T0 961 107551 V523 G T Y K R H P V R P I V H P N
Zebra Danio Brachydanio rerio NP_996977 856 94429 K479 L Q L E L K E K E L L R R E Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95UN8 1161 128942 T512 L P T G F R H T I T A V R D K
Honey Bee Apis mellifera XP_397605 895 101116 R496 G Y K Q C K K R L V H P L L K
Nematode Worm Caenorhab. elegans O01700 928 103465 Q501 A V A A P R A Q L R G Y P N E
Sea Urchin Strong. purpuratus XP_795085 943 105022 L496 E I K K K K S L K P I L K A R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 95.2 97.4 N.A. 92.5 91.7 N.A. N.A. 52.3 51.8 65.4 N.A. 24 38.4 29 38.6
Protein Similarity: 100 95.8 95.6 98.5 N.A. 93.8 93.1 N.A. N.A. 62.5 63.1 74 N.A. 38.4 52.8 44.9 52.8
P-Site Identity: 100 13.3 93.3 93.3 N.A. 93.3 80 N.A. N.A. 46.6 46.6 13.3 N.A. 0 6.6 6.6 13.3
P-Site Similarity: 100 20 93.3 93.3 N.A. 93.3 80 N.A. N.A. 60 60 20 N.A. 13.3 13.3 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 0 0 8 0 0 0 8 0 8 8 0 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 16 0 0 16 0 8 8 0 8 0 8 0 0 8 16 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 62 0 0 8 0 0 0 0 0 24 8 0 0 39 0 % G
% His: 0 0 0 0 0 54 8 0 0 0 8 0 54 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 8 0 24 8 0 0 0 % I
% Lys: 0 0 24 62 8 24 8 8 8 0 0 0 8 0 16 % K
% Leu: 16 47 47 0 8 0 8 16 16 8 47 47 8 16 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 54 % N
% Pro: 0 8 0 0 24 0 47 0 0 24 0 8 8 16 0 % P
% Gln: 0 8 0 8 0 0 0 8 0 0 0 8 0 0 8 % Q
% Arg: 0 0 0 0 24 16 0 8 62 16 0 8 16 0 8 % R
% Ser: 0 0 0 0 16 0 8 39 0 16 0 0 0 0 0 % S
% Thr: 0 16 8 0 8 0 8 8 0 8 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 0 16 0 8 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 16 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _