Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP3K12 All Species: 20.91
Human Site: S540 Identified Species: 38.33
UniProt: Q12852 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12852 NP_006292.2 859 93219 S540 G P P S P G R S R R G K T R H
Chimpanzee Pan troglodytes XP_509099 871 93967 A554 L L P K L D A A L S G V G L P
Rhesus Macaque Macaca mulatta XP_001105474 890 96134 S573 G P P S P G R S R R G K T R H
Dog Lupus familis XP_857182 860 93116 S540 G P P S P G R S R R G K T R H
Cat Felis silvestris
Mouse Mus musculus Q60700 888 96066 S573 G P P S P G R S R R G K T R H
Rat Rattus norvegicus Q63796 888 96289 S573 A P P S P G R S R R G K T R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_422689 966 107967 R586 S A L S G K S R Y R S K P R H
Frog Xenopus laevis A7J1T0 961 107551 G586 T S S G G G K G R Y R S K P R
Zebra Danio Brachydanio rerio NP_996977 856 94429 Q542 K M D A G V L Q V T V P P C S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95UN8 1161 128942 T575 E W P A Q T S T H S S F S K S
Honey Bee Apis mellifera XP_397605 895 101116 S559 T V L A P N N S F K Q R K Y R
Nematode Worm Caenorhab. elegans O01700 928 103465 N564 T R R S E G A N P P K I L R N
Sea Urchin Strong. purpuratus XP_795085 943 105022 A559 A K T S P I R A K T L P Q R K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.7 95.2 97.4 N.A. 92.5 91.7 N.A. N.A. 52.3 51.8 65.4 N.A. 24 38.4 29 38.6
Protein Similarity: 100 95.8 95.6 98.5 N.A. 93.8 93.1 N.A. N.A. 62.5 63.1 74 N.A. 38.4 52.8 44.9 52.8
P-Site Identity: 100 13.3 100 100 N.A. 100 93.3 N.A. N.A. 33.3 13.3 0 N.A. 6.6 13.3 20 26.6
P-Site Similarity: 100 20 100 100 N.A. 100 93.3 N.A. N.A. 33.3 20 6.6 N.A. 33.3 33.3 33.3 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 24 0 0 16 16 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % F
% Gly: 31 0 0 8 24 54 0 8 0 0 47 0 8 0 0 % G
% His: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 47 % H
% Ile: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 8 8 0 8 0 8 8 0 8 8 8 47 16 8 8 % K
% Leu: 8 8 16 0 8 0 8 0 8 0 8 0 8 8 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 8 8 0 0 0 0 0 0 8 % N
% Pro: 0 39 54 0 54 0 0 0 8 8 0 16 16 8 8 % P
% Gln: 0 0 0 0 8 0 0 8 0 0 8 0 8 0 0 % Q
% Arg: 0 8 8 0 0 0 47 8 47 47 8 8 0 62 16 % R
% Ser: 8 8 8 62 0 0 16 47 0 16 16 8 8 0 16 % S
% Thr: 24 0 8 0 0 8 0 8 0 16 0 0 39 0 0 % T
% Val: 0 8 0 0 0 8 0 0 8 0 8 8 0 0 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 8 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _