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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
28.48
Human Site:
S610
Identified Species:
52.22
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S610
L
R
K
M
S
S
S
S
P
D
L
L
S
A
A
Chimpanzee
Pan troglodytes
XP_509099
871
93967
W620
L
G
G
G
P
S
A
W
E
A
C
P
P
A
L
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S640
L
R
K
M
S
S
S
S
P
D
L
L
S
A
A
Dog
Lupus familis
XP_857182
860
93116
S610
L
R
K
M
S
S
S
S
P
D
L
L
S
A
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S643
L
R
K
M
S
S
S
S
P
D
L
L
S
A
A
Rat
Rattus norvegicus
Q63796
888
96289
S643
L
R
K
M
S
S
S
S
P
D
L
L
S
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
S687
Q
R
R
M
S
G
S
S
P
D
L
I
S
T
A
Frog
Xenopus laevis
A7J1T0
961
107551
S692
H
R
R
M
S
G
F
S
P
D
L
L
S
S
T
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
A605
P
P
P
A
A
P
I
A
E
S
V
S
G
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
N640
L
T
R
P
N
N
N
N
I
G
N
C
K
A
I
Honey Bee
Apis mellifera
XP_397605
895
101116
S629
I
P
S
I
E
K
L
S
V
N
S
L
N
K
Q
Nematode Worm
Caenorhab. elegans
O01700
928
103465
T648
A
S
R
R
R
V
S
T
S
V
N
K
S
T
A
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
A686
N
E
G
Q
S
Q
A
A
P
R
K
Y
K
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
N.A.
66.6
60
0
N.A.
13.3
13.3
20
13.3
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
N.A.
80
73.3
26.6
N.A.
46.6
40
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
8
0
16
16
0
8
0
0
0
54
54
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
54
0
0
0
0
0
% D
% Glu:
0
8
0
0
8
0
0
0
16
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
16
8
0
16
0
0
0
8
0
0
8
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
0
8
0
0
8
0
8
0
0
8
0
0
8
% I
% Lys:
0
0
39
0
0
8
0
0
0
0
8
8
16
8
0
% K
% Leu:
54
0
0
0
0
0
8
0
0
0
54
54
0
0
8
% L
% Met:
0
0
0
54
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
8
8
8
8
0
8
16
0
8
0
0
% N
% Pro:
8
16
8
8
8
8
0
0
62
0
0
8
8
0
0
% P
% Gln:
8
0
0
8
0
8
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
54
31
8
8
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
0
8
8
0
62
47
54
62
8
8
8
8
62
16
0
% S
% Thr:
0
8
0
0
0
0
0
8
0
0
0
0
0
16
16
% T
% Val:
0
0
0
0
0
8
0
0
8
8
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _