KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
20.61
Human Site:
S718
Identified Species:
37.78
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S718
R
S
Q
K
R
G
I
S
S
E
E
E
E
G
E
Chimpanzee
Pan troglodytes
XP_509099
871
93967
Q729
G
G
S
R
A
G
S
Q
H
L
T
P
A
A
L
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S748
R
S
Q
K
R
G
I
S
S
E
E
E
E
G
E
Dog
Lupus familis
XP_857182
860
93116
S718
R
S
Q
K
R
G
I
S
S
E
E
E
E
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
S745
Y
R
A
A
V
T
R
S
Q
K
R
G
I
S
S
Rat
Rattus norvegicus
Q63796
888
96289
G749
V
T
R
S
Q
K
R
G
I
S
S
E
E
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
S804
I
Q
K
S
G
D
D
S
S
E
E
E
E
G
E
Frog
Xenopus laevis
A7J1T0
961
107551
S814
L
R
K
N
G
D
D
S
S
E
G
E
E
G
E
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
S706
K
Q
R
R
G
V
S
S
E
E
E
E
G
E
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
S950
S
T
T
S
R
K
S
S
V
T
F
Q
S
V
S
Honey Bee
Apis mellifera
XP_397605
895
101116
I736
L
P
G
H
F
C
G
I
I
V
N
N
T
P
Q
Nematode Worm
Caenorhab. elegans
O01700
928
103465
S765
K
I
V
N
L
P
E
S
T
S
Y
D
E
A
L
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
S789
L
R
K
G
P
G
T
S
K
R
S
P
S
P
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
6.6
100
100
N.A.
6.6
20
N.A.
N.A.
53.3
46.6
26.6
N.A.
13.3
0
13.3
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
13.3
40
N.A.
N.A.
60
53.3
46.6
N.A.
26.6
6.6
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
8
0
0
0
0
0
0
0
8
16
0
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
16
16
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
0
8
47
39
54
54
16
47
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
8
8
8
8
24
39
8
8
0
0
8
8
8
39
0
% G
% His:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
8
0
0
0
0
24
8
16
0
0
0
8
0
0
% I
% Lys:
16
0
24
24
0
16
0
0
8
8
0
0
0
0
0
% K
% Leu:
24
0
0
0
8
0
0
0
0
8
0
0
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
16
0
0
0
0
0
0
8
8
0
0
0
% N
% Pro:
0
8
0
0
8
8
0
0
0
0
0
16
0
16
0
% P
% Gln:
0
16
24
0
8
0
0
8
8
0
0
8
0
0
8
% Q
% Arg:
24
24
16
16
31
0
16
0
0
8
8
0
0
0
0
% R
% Ser:
8
24
8
24
0
0
24
77
39
16
16
0
16
8
16
% S
% Thr:
0
16
8
0
0
8
8
0
8
8
8
0
8
0
8
% T
% Val:
8
0
8
0
8
8
0
0
8
8
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _