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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
19.39
Human Site:
S777
Identified Species:
35.56
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S777
S
G
T
P
E
V
G
S
T
N
T
D
E
R
P
Chimpanzee
Pan troglodytes
XP_509099
871
93967
S788
S
G
T
P
E
V
G
S
T
N
T
D
E
R
P
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S807
S
G
T
P
E
V
G
S
T
N
T
D
E
R
P
Dog
Lupus familis
XP_857182
860
93116
S777
S
G
T
P
E
V
G
S
T
N
T
D
E
R
P
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
G804
A
S
E
P
S
P
S
G
T
P
E
V
G
S
T
Rat
Rattus norvegicus
Q63796
888
96289
V808
S
P
S
G
T
P
E
V
G
S
T
N
T
D
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
A863
S
N
S
P
D
E
Q
A
A
K
L
E
D
E
L
Frog
Xenopus laevis
A7J1T0
961
107551
A873
S
N
S
P
D
D
V
A
C
G
N
K
V
W
Q
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
S765
S
G
T
P
D
V
V
S
T
N
T
D
E
R
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
S1009
S
A
S
P
S
I
A
S
T
E
A
V
N
G
Y
Honey Bee
Apis mellifera
XP_397605
895
101116
R795
L
R
R
R
S
I
A
R
R
P
I
G
P
G
C
Nematode Worm
Caenorhab. elegans
O01700
928
103465
D824
R
S
R
S
D
D
A
D
V
E
S
S
E
E
D
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
H848
R
Q
S
Y
S
T
D
H
S
D
G
I
F
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
100
N.A.
13.3
13.3
N.A.
N.A.
13.3
13.3
80
N.A.
26.6
0
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
20
33.3
N.A.
N.A.
46.6
33.3
86.6
N.A.
40
6.6
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
24
16
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
31
16
8
8
0
8
0
39
8
8
8
% D
% Glu:
0
0
8
0
31
8
8
0
0
16
8
8
47
16
16
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
0
39
0
8
0
0
31
8
8
8
8
8
8
16
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
16
0
0
0
0
8
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% K
% Leu:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
16
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
16
0
0
0
0
0
0
0
39
8
8
8
0
0
% N
% Pro:
0
8
0
70
0
16
0
0
0
16
0
0
8
0
31
% P
% Gln:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
8
% Q
% Arg:
16
8
16
8
0
0
0
8
8
0
0
0
0
39
0
% R
% Ser:
70
16
39
8
31
0
8
47
8
8
8
8
0
16
0
% S
% Thr:
0
0
39
0
8
8
0
0
54
0
47
0
8
0
8
% T
% Val:
0
0
0
0
0
39
16
8
8
0
0
16
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _