KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
47.27
Human Site:
Y440
Identified Species:
86.67
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
Y440
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Chimpanzee
Pan troglodytes
XP_509099
871
93967
Y473
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
Y473
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Dog
Lupus familis
XP_857182
860
93116
Y440
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
Y473
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Rat
Rattus norvegicus
Q63796
888
96289
Y473
L
E
R
A
N
N
L
Y
M
E
L
N
A
L
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
Y486
L
E
R
A
N
N
L
Y
M
E
L
S
A
I
M
Frog
Xenopus laevis
A7J1T0
961
107551
Y486
L
E
R
A
N
N
L
Y
M
E
L
S
S
I
M
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
Y464
L
E
R
A
N
N
L
Y
M
E
L
N
A
V
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
L475
L
R
E
R
E
R
V
L
I
E
R
E
L
V
M
Honey Bee
Apis mellifera
XP_397605
895
101116
Y464
L
E
R
T
N
N
L
Y
L
E
L
S
A
V
L
Nematode Worm
Caenorhab. elegans
O01700
928
103465
Y456
L
K
R
T
N
K
M
Y
D
K
L
Q
G
C
F
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
Y461
L
Q
R
A
N
D
L
Y
M
E
L
H
S
C
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
86.6
80
93.3
N.A.
20
66.6
33.3
60
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
40
93.3
53.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
77
0
0
0
0
0
0
0
0
70
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% C
% Asp:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
77
8
0
8
0
0
0
0
93
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
0
0
16
0
% I
% Lys:
0
8
0
0
0
8
0
0
0
8
0
0
0
0
0
% K
% Leu:
100
0
0
0
0
0
85
8
8
0
93
0
8
47
16
% L
% Met:
0
0
0
0
0
0
8
0
77
0
0
0
0
0
77
% M
% Asn:
0
0
0
0
93
77
0
0
0
0
0
54
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
8
93
8
0
8
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
24
16
0
0
% S
% Thr:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
24
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _