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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DPYD All Species: 36.06
Human Site: S440 Identified Species: 72.12
UniProt: Q12882 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12882 NP_000101.2 1025 111401 S440 V V I S A F G S V L S D P K V
Chimpanzee Pan troglodytes XP_513583 1219 132523 S634 V V I S A F G S V L S D P K V
Rhesus Macaque Macaca mulatta XP_001106007 1025 111542 S440 V V I S A F G S V L S D P K V
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CHR6 1025 111235 S440 V V I S A F G S V L E D P K V
Rat Rattus norvegicus O89000 1025 111449 S440 V V I S P F G S V L D D P K V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426639 1178 126824 S593 V V I S A F G S V L S D S K V
Frog Xenopus laevis NP_001087488 940 101737 S404 T L K G G K I S G M E F V R T
Zebra Danio Brachydanio rerio Q6NYG8 1022 110985 S440 F I I S A F G S M L N D P A V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572538 1031 111207 A436 K A N F V I S A F G S G L E D
Honey Bee Apis mellifera XP_393690 1024 112012 S438 F V I S A F G S G L Q N Q D V
Nematode Worm Caenorhab. elegans Q18164 1059 115282 S454 Y V I S A F G S T L K E D A V
Sea Urchin Strong. purpuratus XP_001177822 1025 111109 S440 F I I S A F G S T L L N E E V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.8 98.3 N.A. N.A. 89.5 89.1 N.A. N.A. 72.4 74.2 76.2 N.A. 65.6 66.8 63.9 71.3
Protein Similarity: 100 83.8 99.3 N.A. N.A. 94.9 94.4 N.A. N.A. 79.1 82.2 86.4 N.A. 76.8 80.7 77.1 83.7
P-Site Identity: 100 100 100 N.A. N.A. 93.3 86.6 N.A. N.A. 93.3 6.6 66.6 N.A. 6.6 60 60 53.3
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 86.6 N.A. N.A. 93.3 26.6 86.6 N.A. 20 66.6 66.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 75 0 0 9 0 0 0 0 0 17 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 9 59 9 9 9 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 17 9 9 17 0 % E
% Phe: 25 0 0 9 0 84 0 0 9 0 0 9 0 0 0 % F
% Gly: 0 0 0 9 9 0 84 0 17 9 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 17 84 0 0 9 9 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 9 0 0 9 0 0 0 0 9 0 0 50 0 % K
% Leu: 0 9 0 0 0 0 0 0 0 84 9 0 9 0 0 % L
% Met: 0 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 0 9 17 0 0 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 0 0 0 50 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 9 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % R
% Ser: 0 0 0 84 0 0 9 92 0 0 42 0 9 0 0 % S
% Thr: 9 0 0 0 0 0 0 0 17 0 0 0 0 0 9 % T
% Val: 50 67 0 0 9 0 0 0 50 0 0 0 9 0 84 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _