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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DPYD All Species: 25.76
Human Site: S452 Identified Species: 51.52
UniProt: Q12882 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12882 NP_000101.2 1025 111401 S452 P K V K E A L S P I K F N R W
Chimpanzee Pan troglodytes XP_513583 1219 132523 S646 P K V K E A L S P I K F N R W
Rhesus Macaque Macaca mulatta XP_001106007 1025 111542 S452 P K V K E A L S P I K F N R W
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CHR6 1025 111235 S452 P K V K E A L S P I K F N R W
Rat Rattus norvegicus O89000 1025 111449 S452 P K V I E A L S P I K F N R W
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426639 1178 126824 T605 S K V I E A M T P I K F N R W
Frog Xenopus laevis NP_001087488 940 101737 D416 V R T E Q D D D G N W I E D E
Zebra Danio Brachydanio rerio Q6NYG8 1022 110985 D452 P A V T K A L D P I K L N R W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572538 1031 111207 A448 L E D Q D V K A A L A P L Q F
Honey Bee Apis mellifera XP_393690 1024 112012 V450 Q D V I Q A M V P I K M N K W
Nematode Worm Caenorhab. elegans Q18164 1059 115282 Q466 D A V L S A L Q P C Q L N K W
Sea Urchin Strong. purpuratus XP_001177822 1025 111109 S452 E E V K T A L S P I R F N R W
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.8 98.3 N.A. N.A. 89.5 89.1 N.A. N.A. 72.4 74.2 76.2 N.A. 65.6 66.8 63.9 71.3
Protein Similarity: 100 83.8 99.3 N.A. N.A. 94.9 94.4 N.A. N.A. 79.1 82.2 86.4 N.A. 76.8 80.7 77.1 83.7
P-Site Identity: 100 100 100 N.A. N.A. 100 93.3 N.A. N.A. 73.3 0 66.6 N.A. 0 46.6 40 73.3
P-Site Similarity: 100 100 100 N.A. N.A. 100 93.3 N.A. N.A. 86.6 20 73.3 N.A. 46.6 66.6 53.3 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 0 0 84 0 9 9 0 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % C
% Asp: 9 9 9 0 9 9 9 17 0 0 0 0 0 9 0 % D
% Glu: 9 17 0 9 50 0 0 0 0 0 0 0 9 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 59 0 0 9 % F
% Gly: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 25 0 0 0 0 0 75 0 9 0 0 0 % I
% Lys: 0 50 0 42 9 0 9 0 0 0 67 0 0 17 0 % K
% Leu: 9 0 0 9 0 0 67 0 0 9 0 17 9 0 0 % L
% Met: 0 0 0 0 0 0 17 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 9 0 0 84 0 0 % N
% Pro: 50 0 0 0 0 0 0 0 84 0 0 9 0 0 0 % P
% Gln: 9 0 0 9 17 0 0 9 0 0 9 0 0 9 0 % Q
% Arg: 0 9 0 0 0 0 0 0 0 0 9 0 0 67 0 % R
% Ser: 9 0 0 0 9 0 0 50 0 0 0 0 0 0 0 % S
% Thr: 0 0 9 9 9 0 0 9 0 0 0 0 0 0 0 % T
% Val: 9 0 84 0 0 9 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 84 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _