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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DPYD
All Species:
28.48
Human Site:
Y276
Identified Species:
56.97
UniProt:
Q12882
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12882
NP_000101.2
1025
111401
Y276
S
T
L
K
E
K
G
Y
K
A
A
F
I
G
I
Chimpanzee
Pan troglodytes
XP_513583
1219
132523
Y470
S
T
L
K
E
K
G
Y
K
A
A
F
I
G
I
Rhesus Macaque
Macaca mulatta
XP_001106007
1025
111542
Y276
S
T
L
K
E
K
G
Y
K
A
A
F
I
G
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHR6
1025
111235
Y276
S
S
L
K
E
N
G
Y
R
A
A
F
I
G
I
Rat
Rattus norvegicus
O89000
1025
111449
Y276
S
T
L
K
E
N
G
Y
K
A
A
F
I
G
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_426639
1178
126824
Y436
R
T
L
K
E
D
G
Y
E
A
V
F
I
G
I
Frog
Xenopus laevis
NP_001087488
940
101737
F276
R
S
L
K
E
E
G
F
K
A
I
F
I
G
I
Zebra Danio
Brachydanio rerio
Q6NYG8
1022
110985
Y276
T
S
L
K
E
E
G
Y
Q
V
V
Y
I
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572538
1031
111207
H273
Q
G
L
L
S
T
G
H
D
A
V
F
V
G
I
Honey Bee
Apis mellifera
XP_393690
1024
112012
Y273
E
S
L
Q
N
S
G
Y
K
A
I
F
L
G
I
Nematode Worm
Caenorhab. elegans
Q18164
1059
115282
A289
A
K
L
K
E
Q
G
A
A
A
V
F
I
G
I
Sea Urchin
Strong. purpuratus
XP_001177822
1025
111109
Q276
E
S
L
K
S
S
G
Q
E
A
I
F
V
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.8
98.3
N.A.
N.A.
89.5
89.1
N.A.
N.A.
72.4
74.2
76.2
N.A.
65.6
66.8
63.9
71.3
Protein Similarity:
100
83.8
99.3
N.A.
N.A.
94.9
94.4
N.A.
N.A.
79.1
82.2
86.4
N.A.
76.8
80.7
77.1
83.7
P-Site Identity:
100
100
100
N.A.
N.A.
80
93.3
N.A.
N.A.
73.3
66.6
53.3
N.A.
40
53.3
60
40
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
N.A.
80
86.6
86.6
N.A.
53.3
73.3
73.3
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
9
9
92
42
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
0
9
0
0
0
0
0
0
% D
% Glu:
17
0
0
0
75
17
0
0
17
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
92
0
0
0
% F
% Gly:
0
9
0
0
0
0
100
0
0
0
0
0
0
100
0
% G
% His:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
25
0
75
0
92
% I
% Lys:
0
9
0
84
0
25
0
0
50
0
0
0
0
0
0
% K
% Leu:
0
0
100
9
0
0
0
0
0
0
0
0
9
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
9
17
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
9
0
0
9
0
9
0
9
9
0
0
0
0
0
0
% Q
% Arg:
17
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% R
% Ser:
42
42
0
0
17
17
0
0
0
0
0
0
0
0
0
% S
% Thr:
9
42
0
0
0
9
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
34
0
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
67
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _