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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DPYD All Species: 22.73
Human Site: Y511 Identified Species: 45.45
UniProt: Q12882 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12882 NP_000101.2 1025 111401 Y511 H K Y V Q S Q Y G A S V S A K
Chimpanzee Pan troglodytes XP_513583 1219 132523 Y705 H K Y V Q S Q Y G A S V S A K
Rhesus Macaque Macaca mulatta XP_001106007 1025 111542 Y511 H K Y I Q S Q Y G A S I S A K
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8CHR6 1025 111235 Y511 H K H I Q A Q Y G T S V P S Q
Rat Rattus norvegicus O89000 1025 111449 Y511 H E Y I Q A Q Y G A L V P S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426639 1178 126824 Y664 H R Y I Q S L Y G A V V S T T
Frog Xenopus laevis NP_001087488 940 101737 E473 P E T M Q T S E A G V F V G G
Zebra Danio Brachydanio rerio Q6NYG8 1022 110985 H511 H K Y I Q S L H G N T I S A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572538 1031 111207 Q506 W S I H C Q L Q G L P L D T P
Honey Bee Apis mellifera XP_393690 1024 112012 Y509 H K F I Q N S Y N L E V P K I
Nematode Worm Caenorhab. elegans Q18164 1059 115282 H525 H R Y I Q S L H G N Q V S E T
Sea Urchin Strong. purpuratus XP_001177822 1025 111109 H511 H K Y L Q S L H G V P V P S T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.8 98.3 N.A. N.A. 89.5 89.1 N.A. N.A. 72.4 74.2 76.2 N.A. 65.6 66.8 63.9 71.3
Protein Similarity: 100 83.8 99.3 N.A. N.A. 94.9 94.4 N.A. N.A. 79.1 82.2 86.4 N.A. 76.8 80.7 77.1 83.7
P-Site Identity: 100 100 86.6 N.A. N.A. 53.3 53.3 N.A. N.A. 60 6.6 53.3 N.A. 6.6 33.3 46.6 46.6
P-Site Similarity: 100 100 100 N.A. N.A. 86.6 86.6 N.A. N.A. 73.3 26.6 80 N.A. 13.3 53.3 66.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 17 0 0 9 42 0 0 0 34 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % D
% Glu: 0 17 0 0 0 0 0 9 0 0 9 0 0 9 0 % E
% Phe: 0 0 9 0 0 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 84 9 0 0 0 9 9 % G
% His: 84 0 9 9 0 0 0 25 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 59 0 0 0 0 0 0 0 17 0 0 9 % I
% Lys: 0 59 0 0 0 0 0 0 0 0 0 0 0 9 25 % K
% Leu: 0 0 0 9 0 0 42 0 0 17 9 9 0 0 0 % L
% Met: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 9 17 0 0 0 0 0 % N
% Pro: 9 0 0 0 0 0 0 0 0 0 17 0 34 0 9 % P
% Gln: 0 0 0 0 92 9 42 9 0 0 9 0 0 0 17 % Q
% Arg: 0 17 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 9 0 0 0 59 17 0 0 0 34 0 50 25 0 % S
% Thr: 0 0 9 0 0 9 0 0 0 9 9 0 0 17 34 % T
% Val: 0 0 0 17 0 0 0 0 0 9 17 67 9 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 67 0 0 0 0 59 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _