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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FAP All Species: 37.88
Human Site: Y625 Identified Species: 75.76
UniProt: Q12884 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12884 NP_004451.2 760 87713 Y625 I A I W G W S Y G G Y V S S L
Chimpanzee Pan troglodytes Q5IS50 803 91393 L655 G K D Y G G Y L S T Y I L P A
Rhesus Macaque Macaca mulatta XP_001096858 760 87738 Y625 I A I W G W S Y G G Y V S S L
Dog Lupus familis XP_850205 760 87694 Y625 I A I W G W S Y G G Y V S S L
Cat Felis silvestris
Mouse Mus musculus P97321 761 87926 Y625 I A I W G W S Y G G Y V S S L
Rat Rattus norvegicus P14740 767 88070 Y632 V A I W G W S Y G G Y V T S M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512952 760 87513 Y624 I A I W G W S Y G G Y V S S L
Chicken Gallus gallus NP_001026426 759 86325 Y625 I A I W G W S Y G G Y V T S M
Frog Xenopus laevis NP_001079272 755 86900 Y622 I A I W G W S Y G G Y V T S M
Zebra Danio Brachydanio rerio XP_001920834 793 90752 Y660 I A M W G W S Y G G Y V T S M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q18253 829 94369 S691 R I A V M G W S Y G G F L T S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P18962 818 93386 S679 K I S L F G W S Y G G Y L T L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 31.2 99.6 93.4 N.A. 89.6 52.7 N.A. 83.9 55.1 58 49.8 N.A. N.A. N.A. 28.3 N.A.
Protein Similarity: 100 54.1 99.7 97.5 N.A. 94.4 72.4 N.A. 92.3 72.5 75.2 68.7 N.A. N.A. N.A. 44.3 N.A.
P-Site Identity: 100 13.3 100 100 N.A. 100 80 N.A. 100 86.6 86.6 80 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 26.6 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 75 9 0 0 0 0 0 0 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 9 0 0 0 % F
% Gly: 9 0 0 0 84 25 0 0 75 92 17 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 67 17 67 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 0 0 0 9 0 0 0 0 25 0 50 % L
% Met: 0 0 9 0 9 0 0 0 0 0 0 0 0 0 34 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 9 0 0 0 75 17 9 0 0 0 42 75 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 9 0 0 34 17 0 % T
% Val: 9 0 0 9 0 0 0 0 0 0 0 75 0 0 0 % V
% Trp: 0 0 0 75 0 75 17 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 0 0 9 75 17 0 84 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _