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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COX10 All Species: 18.48
Human Site: S81 Identified Species: 29.05
UniProt: Q12887 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12887 NP_001294.2 443 48910 S81 P K P E P V A S P F L E K T S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001114525 443 49311 S81 P K P E P V A S P F L E K T S
Dog Lupus familis XP_546634 787 85953 L424 R K P E P V A L P F L E K T S
Cat Felis silvestris
Mouse Mus musculus Q8CFY5 443 48865 S81 P K P E P P A S P F L E H T S
Rat Rattus norvegicus XP_001077717 442 48686 S81 P K P A P P A S P L L E H T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509146 496 53440 K137 R D L S Q R A K P K P E P S T
Chicken Gallus gallus NP_001025871 448 49551 F80 S D S V V S P F R E S Q L D Q
Frog Xenopus laevis NP_001090414 419 46090 V68 P E T V E S S V Q E E T I V Q
Zebra Danio Brachydanio rerio XP_685590 543 59752 R174 S S S G L C Q R A R P R Q E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609382 391 42543 T40 S Q D D K G V T T A S P V S Q
Honey Bee Apis mellifera XP_392628 418 47202 D67 S F V T P I G D Q K N T Q Y V
Nematode Worm Caenorhab. elegans NP_496708 397 43594 S46 D E E M P L A S P K K P R P D
Sea Urchin Strong. purpuratus XP_001193030 440 47997 S79 T K P H L K D S E S S Q E V L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P21592 462 52129 T97 R C T D D I S T S S G S E A T
Red Bread Mold Neurospora crassa Q7S5E7 535 56994 A108 S T T Q P T T A A D L P P V D
Conservation
Percent
Protein Identity: 100 N.A. 94.8 48.5 N.A. 82.1 81.7 N.A. 63.7 67.8 61.4 51 N.A. 45.8 42.8 40.6 44.4
Protein Similarity: 100 N.A. 96.3 52.2 N.A. 88.7 88.2 N.A. 70.3 79.9 72.9 62.7 N.A. 59.1 58.2 54.6 59.8
P-Site Identity: 100 N.A. 100 86.6 N.A. 86.6 73.3 N.A. 20 0 6.6 0 N.A. 0 6.6 26.6 20
P-Site Similarity: 100 N.A. 100 86.6 N.A. 86.6 73.3 N.A. 33.3 6.6 20 6.6 N.A. 26.6 20 46.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.8 30.4
Protein Similarity: N.A. N.A. N.A. N.A. 48.7 43.9
P-Site Identity: N.A. N.A. N.A. N.A. 0 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 40 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 47 7 14 7 0 0 0 7 0 % A
% Cys: 0 7 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 14 7 14 7 0 7 7 0 7 0 0 0 7 14 % D
% Glu: 0 14 7 27 7 0 0 0 7 14 7 40 14 7 0 % E
% Phe: 0 7 0 0 0 0 0 7 0 27 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 7 7 0 0 0 7 0 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 14 0 0 % H
% Ile: 0 0 0 0 0 14 0 0 0 0 0 0 7 0 0 % I
% Lys: 0 40 0 0 7 7 0 7 0 20 7 0 20 0 0 % K
% Leu: 0 0 7 0 14 7 0 7 0 7 40 0 7 0 7 % L
% Met: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % N
% Pro: 34 0 40 0 54 14 7 0 47 0 14 20 14 7 7 % P
% Gln: 0 7 0 7 7 0 7 0 14 0 0 14 14 0 20 % Q
% Arg: 20 0 0 0 0 7 0 7 7 7 0 7 7 0 0 % R
% Ser: 34 7 14 7 0 14 14 40 7 14 20 7 0 14 34 % S
% Thr: 7 7 20 7 0 7 7 14 7 0 0 14 0 34 14 % T
% Val: 0 0 7 14 7 20 7 7 0 0 0 0 7 20 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _