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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HYAL2 All Species: 22.73
Human Site: Y177 Identified Species: 55.56
UniProt: Q12891 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12891 NP_003764.3 473 53844 Y177 R I V K Q A Q Y E F E F A A Q
Chimpanzee Pan troglodytes XP_001168504 473 53826 Y177 R I V K Q A Q Y E F E F A A Q
Rhesus Macaque Macaca mulatta XP_001101134 473 53962 Y177 R I V K Q A Q Y E F E F A A Q
Dog Lupus familis XP_541876 472 53416 Y176 R V V K Q A Q Y E F E F A A R
Cat Felis silvestris
Mouse Mus musculus O35632 473 53599 Y177 R V M K Q A Q Y E F E F A A R
Rat Rattus norvegicus Q9Z2Q3 473 53981 Y177 R I V K Q A Q Y E F E F A A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507872 472 54425 K166 K V K T V A Q K E F E K A G K
Chicken Gallus gallus XP_414258 478 54697 F186 K V N K Q A V F E F E S A A R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_687640 502 57507 Q207 Q V T K V A Q Q E F E L S A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera Q08169 382 44241 N102 L L K D P N G N V V A R N G G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.3 89 N.A. 82.2 81.6 N.A. 42.4 55.4 N.A. 45.2 N.A. N.A. 26.4 N.A. N.A.
Protein Similarity: 100 100 98.5 92.8 N.A. 90 89 N.A. 61 69.4 N.A. 63.1 N.A. N.A. 42.7 N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 80 93.3 N.A. 40 53.3 N.A. 46.6 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 60 80 N.A. 73.3 N.A. N.A. 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 90 0 0 0 0 10 0 80 80 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 90 0 90 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 10 0 90 0 60 0 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 20 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 40 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 20 0 20 80 0 0 0 10 0 0 0 10 0 0 10 % K
% Leu: 10 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 0 0 10 0 10 0 0 0 0 10 0 0 % N
% Pro: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 10 0 0 0 70 0 80 10 0 0 0 0 0 0 30 % Q
% Arg: 60 0 0 0 0 0 0 0 0 0 0 10 0 0 50 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % S
% Thr: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 50 50 0 20 0 10 0 10 10 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _