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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MYO1E All Species: 18.18
Human Site: S226 Identified Species: 33.33
UniProt: Q12965 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12965 NP_004989.2 1108 127062 S226 A S A E Q K H S L G I T S M D
Chimpanzee Pan troglodytes XP_510448 1108 126943 S226 A S A E Q K H S L G I T S M D
Rhesus Macaque Macaca mulatta XP_001100995 715 80188
Dog Lupus familis XP_535500 1130 129758 S248 A S A E Q K H S L G I T S M D
Cat Felis silvestris
Mouse Mus musculus P70248 1099 125929 G226 Q E Q Q Q N L G I M S Q D Y Y
Rat Rattus norvegicus Q63356 1107 126808 S226 A S P E Q K Q S L G I T S M D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZLA6 1028 118889 E223 L L R R L G L E K N P Q Q Y H
Frog Xenopus laevis NP_001080439 1094 125660 I227 E D K E N L G I T S P D Y Y F
Zebra Danio Brachydanio rerio XP_682849 1163 133360 S283 A S G D Q K S S L G I T S L D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_492393 1100 124867 Y230 G I G E L Q Y Y N Y L N M S G
Sea Urchin Strong. purpuratus NP_001118234 1118 127023 P226 E N L G L T T P D Y Y F Y L N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04439 1219 136881 Q243 G A S D A Y R Q T F G V Q K P
Red Bread Mold Neurospora crassa Q7SDM3 1235 136290 M249 A S Q Q Y R E M Y G I Q K P E
Conservation
Percent
Protein Identity: 100 99.6 49.9 96.2 N.A. 70.4 95.6 N.A. N.A. 35.8 75.5 77.7 N.A. N.A. N.A. 56.9 63.4
Protein Similarity: 100 99.8 56.5 97.4 N.A. 82 98 N.A. N.A. 54.2 86.6 86.6 N.A. N.A. N.A. 71.7 78.7
P-Site Identity: 100 100 0 100 N.A. 6.6 86.6 N.A. N.A. 0 6.6 73.3 N.A. N.A. N.A. 6.6 0
P-Site Similarity: 100 100 0 100 N.A. 20 86.6 N.A. N.A. 0 6.6 86.6 N.A. N.A. N.A. 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37.7 38
Protein Similarity: N.A. N.A. N.A. N.A. 55.5 54.9
P-Site Identity: N.A. N.A. N.A. N.A. 0 26.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 47 8 24 0 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 16 0 0 0 0 8 0 0 8 8 0 39 % D
% Glu: 16 8 0 47 0 0 8 8 0 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 8 % F
% Gly: 16 0 16 8 0 8 8 8 0 47 8 0 0 0 8 % G
% His: 0 0 0 0 0 0 24 0 0 0 0 0 0 0 8 % H
% Ile: 0 8 0 0 0 0 0 8 8 0 47 0 0 0 0 % I
% Lys: 0 0 8 0 0 39 0 0 8 0 0 0 8 8 0 % K
% Leu: 8 8 8 0 24 8 16 0 39 0 8 0 0 16 0 % L
% Met: 0 0 0 0 0 0 0 8 0 8 0 0 8 31 0 % M
% Asn: 0 8 0 0 8 8 0 0 8 8 0 8 0 0 8 % N
% Pro: 0 0 8 0 0 0 0 8 0 0 16 0 0 8 8 % P
% Gln: 8 0 16 16 47 8 8 8 0 0 0 24 16 0 0 % Q
% Arg: 0 0 8 8 0 8 8 0 0 0 0 0 0 0 0 % R
% Ser: 0 47 8 0 0 0 8 39 0 8 8 0 39 8 0 % S
% Thr: 0 0 0 0 0 8 8 0 16 0 0 39 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 8 8 8 8 16 8 0 16 24 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _