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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CSTF3 All Species: 27.58
Human Site: T521 Identified Species: 46.67
UniProt: Q12996 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12996 NP_001317.1 717 82922 T521 E E Y E G K E T A L L V D R Y
Chimpanzee Pan troglodytes XP_001143931 749 86255 T553 E E Y E G K E T A L L V D R Y
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533159 717 82899 T521 E E Y E G K E T A L L V D R Y
Cat Felis silvestris
Mouse Mus musculus Q99LI7 717 82858 T521 E E Y E G K E T A L L V D R Y
Rat Rattus norvegicus NP_001071140 590 69247 Y450 I P E Y V L A Y I D Y L S H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507079 820 94279 T624 E E Y E G K E T A L L V D R Y
Chicken Gallus gallus NP_001012586 718 83053 T522 E E Y E G K E T A L L V D R Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_998218 716 82797 T521 D E Y E G K E T A L L V D R Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P25991 765 88196 K554 N L K E Y E G K E T A Q L V D
Honey Bee Apis mellifera XP_393870 713 82097 K518 K I K E F E G K E T A Q L V D
Nematode Worm Caenorhab. elegans NP_495825 735 84603 M509 E A Q K D Q T M N H S M L V I
Sea Urchin Strong. purpuratus XP_796577 557 65419 V417 R S K Y H V Y V A A A L M E Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P25298 677 79942 I522 D L T Q L K E I Y K K M I S Y
Red Bread Mold Neurospora crassa Q7S1Y0 1167 128472 L843 L F P E D P K L A A F T A R Y
Conservation
Percent
Protein Identity: 100 95.7 N.A. 99.8 N.A. 99.3 78.5 N.A. 85.9 98 N.A. 90.7 N.A. 53.5 62.6 48.7 56.9
Protein Similarity: 100 95.7 N.A. 99.8 N.A. 99.5 79.9 N.A. 86.7 99.3 N.A. 95.4 N.A. 71.6 78.2 68.4 67.2
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 100 100 N.A. 93.3 N.A. 6.6 6.6 6.6 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 6.6 N.A. 100 100 N.A. 100 N.A. 13.3 20 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.5 21.6
Protein Similarity: N.A. N.A. N.A. N.A. 46.7 35.3
P-Site Identity: N.A. N.A. N.A. N.A. 20 26.6
P-Site Similarity: N.A. N.A. N.A. N.A. 40 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 8 0 65 15 22 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 15 0 0 0 15 0 0 0 0 8 0 0 50 0 15 % D
% Glu: 50 50 8 72 0 15 58 0 15 0 0 0 0 8 0 % E
% Phe: 0 8 0 0 8 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 0 50 0 15 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 8 0 0 0 8 0 % H
% Ile: 8 8 0 0 0 0 0 8 8 0 0 0 8 0 8 % I
% Lys: 8 0 22 8 0 58 8 15 0 8 8 0 0 0 0 % K
% Leu: 8 15 0 0 8 8 0 8 0 50 50 15 22 0 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 15 8 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 8 8 0 0 8 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 8 8 0 8 0 0 0 0 0 15 0 0 0 % Q
% Arg: 8 0 0 0 0 0 0 0 0 0 0 0 0 58 0 % R
% Ser: 0 8 0 0 0 0 0 0 0 0 8 0 8 8 0 % S
% Thr: 0 0 8 0 0 0 8 50 0 15 0 8 0 0 0 % T
% Val: 0 0 0 0 8 8 0 8 0 0 0 50 0 22 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 50 15 8 0 8 8 8 0 8 0 0 0 72 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _