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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FLII All Species: 26.36
Human Site: S112 Identified Species: 52.73
UniProt: Q13045 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13045 NP_002009.1 1269 144751 S112 D L S V L D L S H N Q L T E C
Chimpanzee Pan troglodytes XP_511321 1458 164815 P284 S L K N S G V P D D I F K L D
Rhesus Macaque Macaca mulatta XP_001094628 1256 143248 S112 D L S V L D L S H N Q L T E C
Dog Lupus familis XP_536659 1147 130372 E112 L S Y N Q L T E C P R E L E N
Cat Felis silvestris
Mouse Mus musculus Q9JJ28 1271 144785 S112 D L S V L D L S H N Q L T E C
Rat Rattus norvegicus NP_001008280 1270 144839 S112 D L S V L D L S H N Q L T E C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001025806 1265 144848 S112 D L S V L D L S R N D L T E C
Frog Xenopus laevis NP_001086319 1270 145779 S112 D L S V L D L S Y N Q L S E C
Zebra Danio Brachydanio rerio XP_688770 1259 143734 S112 D L S V L D L S H N Q L T E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24020 1256 143664 E114 L S H N K L K E V P E G L E R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34268 1257 144797 Q114 I I D L S R N Q L R E V P T N
Sea Urchin Strong. purpuratus XP_790260 1140 130867 P112 F N N I K E I P S Q L F M N L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.3 97.2 86.8 N.A. 95.1 95.1 N.A. N.A. 87.7 82.8 83.6 N.A. 57.2 N.A. 51.1 50.5
Protein Similarity: 100 84.5 98.1 88 N.A. 96.8 96.7 N.A. N.A. 93.3 91.8 91.4 N.A. 74.1 N.A. 69.9 67.9
P-Site Identity: 100 6.6 100 6.6 N.A. 100 100 N.A. N.A. 86.6 86.6 93.3 N.A. 6.6 N.A. 0 0
P-Site Similarity: 100 20 100 13.3 N.A. 100 100 N.A. N.A. 86.6 100 93.3 N.A. 13.3 N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 50 % C
% Asp: 59 0 9 0 0 59 0 0 9 9 9 0 0 0 9 % D
% Glu: 0 0 0 0 0 9 0 17 0 0 17 9 0 75 0 % E
% Phe: 9 0 0 0 0 0 0 0 0 0 0 17 0 0 0 % F
% Gly: 0 0 0 0 0 9 0 0 0 0 0 9 0 0 0 % G
% His: 0 0 9 0 0 0 0 0 42 0 0 0 0 0 0 % H
% Ile: 9 9 0 9 0 0 9 0 0 0 9 0 0 0 9 % I
% Lys: 0 0 9 0 17 0 9 0 0 0 0 0 9 0 0 % K
% Leu: 17 67 0 9 59 17 59 0 9 0 9 59 17 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % M
% Asn: 0 9 9 25 0 0 9 0 0 59 0 0 0 9 17 % N
% Pro: 0 0 0 0 0 0 0 17 0 17 0 0 9 0 0 % P
% Gln: 0 0 0 0 9 0 0 9 0 9 50 0 0 0 0 % Q
% Arg: 0 0 0 0 0 9 0 0 9 9 9 0 0 0 9 % R
% Ser: 9 17 59 0 17 0 0 59 9 0 0 0 9 0 0 % S
% Thr: 0 0 0 0 0 0 9 0 0 0 0 0 50 9 0 % T
% Val: 0 0 0 59 0 0 9 0 9 0 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 0 9 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _