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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FLII All Species: 16.97
Human Site: S822 Identified Species: 33.94
UniProt: Q13045 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13045 NP_002009.1 1269 144751 S822 R H A T V S R S L E G T E A Q
Chimpanzee Pan troglodytes XP_511321 1458 164815 S1010 R H A T V S R S L E G T E A Q
Rhesus Macaque Macaca mulatta XP_001094628 1256 143248 S821 R H A T V S R S L E G T E A Q
Dog Lupus familis XP_536659 1147 130372 L756 A D L T A L F L P R Q P P M A
Cat Felis silvestris
Mouse Mus musculus Q9JJ28 1271 144785 S822 R H T V V S R S L E G T E A Q
Rat Rattus norvegicus NP_001008280 1270 144839 S822 R H T V V S R S L E G T E A Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001025806 1265 144848 N821 K H A M V T R N L E G T E C Q
Frog Xenopus laevis NP_001086319 1270 145779 N823 K H S I V I R N L E G T E C Q
Zebra Danio Brachydanio rerio XP_688770 1259 143734 N821 K H A V V I R N L E G T E C Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24020 1256 143664 V813 D Y A L V M R V P E G N E M Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34268 1257 144797 E822 D Y A Q V Y R E T E G E E S M
Sea Urchin Strong. purpuratus XP_790260 1140 130867 L754 S Q E L C S M L N R P T N A T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.3 97.2 86.8 N.A. 95.1 95.1 N.A. N.A. 87.7 82.8 83.6 N.A. 57.2 N.A. 51.1 50.5
Protein Similarity: 100 84.5 98.1 88 N.A. 96.8 96.7 N.A. N.A. 93.3 91.8 91.4 N.A. 74.1 N.A. 69.9 67.9
P-Site Identity: 100 100 100 6.6 N.A. 86.6 86.6 N.A. N.A. 66.6 60 66.6 N.A. 46.6 N.A. 40 20
P-Site Similarity: 100 100 100 6.6 N.A. 86.6 86.6 N.A. N.A. 86.6 80 80 N.A. 53.3 N.A. 53.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 59 0 9 0 0 0 0 0 0 0 0 50 9 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 25 0 % C
% Asp: 17 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 9 0 0 0 0 9 0 84 0 9 84 0 0 % E
% Phe: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 84 0 0 0 0 % G
% His: 0 67 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 9 0 17 0 0 0 0 0 0 0 0 0 % I
% Lys: 25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 9 17 0 9 0 17 67 0 0 0 0 0 0 % L
% Met: 0 0 0 9 0 9 9 0 0 0 0 0 0 17 9 % M
% Asn: 0 0 0 0 0 0 0 25 9 0 0 9 9 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 17 0 9 9 9 0 0 % P
% Gln: 0 9 0 9 0 0 0 0 0 0 9 0 0 0 75 % Q
% Arg: 42 0 0 0 0 0 84 0 0 17 0 0 0 0 0 % R
% Ser: 9 0 9 0 0 50 0 42 0 0 0 0 0 9 0 % S
% Thr: 0 0 17 34 0 9 0 0 9 0 0 75 0 0 9 % T
% Val: 0 0 0 25 84 0 0 9 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 17 0 0 0 9 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _