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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GPS1 All Species: 27.27
Human Site: S223 Identified Species: 46.15
UniProt: Q13098 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13098 NP_004118.3 491 55537 S223 S H V L S Y V S K A E S T P E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113420 433 48068 K186 E K L D T D L K N Y K G N S I
Dog Lupus familis XP_540496 449 50983 E195 E I A E Q R G E R D S Q T Q A
Cat Felis silvestris
Mouse Mus musculus Q99LD4 471 53424 S203 S H V L S Y V S K A E S T P E
Rat Rattus norvegicus P97834 471 53410 S203 S H V L S Y V S K A E S T P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6NRT5 487 55254 S219 S H V L S Y V S K A E S T P E
Zebra Danio Brachydanio rerio NP_001071227 487 55157 S219 S H V L S Y V S K A E S T P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVU5 525 58196 S255 A H V M S Y I S K A E S T P D
Honey Bee Apis mellifera XP_392872 477 54446 T217 A H V L S Y V T K A E S T P D
Nematode Worm Caenorhab. elegans Q9GS00 601 68384 N260 G K L D T V T N T A Y R S L K
Sea Urchin Strong. purpuratus XP_787846 462 52442 N215 S H V L S Y V N K A E A T P E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P45432 441 50560 V195 E M G Q F T H V T S Y V N K A
Baker's Yeast Sacchar. cerevisiae Q06103 429 48940 D183 R L G F F Y N D Q L Y V K E K
Red Bread Mold Neurospora crassa Q7RXQ1 425 47810 N179 G N H L K P L N S V N D S D P
Conservation
Percent
Protein Identity: 100 N.A. 78.4 89.4 N.A. 93.8 93.6 N.A. N.A. N.A. 92.6 92.2 N.A. 60.9 67.4 25.6 65.5
Protein Similarity: 100 N.A. 79.4 90.6 N.A. 95.1 95.1 N.A. N.A. N.A. 96.9 95.7 N.A. 77.3 79.2 42.5 80
P-Site Identity: 100 N.A. 0 6.6 N.A. 100 100 N.A. N.A. N.A. 100 100 N.A. 73.3 80 6.6 86.6
P-Site Similarity: 100 N.A. 26.6 13.3 N.A. 100 100 N.A. N.A. N.A. 100 100 N.A. 100 100 40 100
Percent
Protein Identity: N.A. N.A. N.A. 43.3 23.6 29.1
Protein Similarity: N.A. N.A. N.A. 58.8 40.5 49.9
P-Site Identity: N.A. N.A. N.A. 0 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 6.6 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 0 8 0 0 0 0 0 0 65 0 8 0 0 15 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 15 0 8 0 8 0 8 0 8 0 8 15 % D
% Glu: 22 0 0 8 0 0 0 8 0 0 58 0 0 8 43 % E
% Phe: 0 0 0 8 15 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 15 0 15 0 0 0 8 0 0 0 0 8 0 0 0 % G
% His: 0 58 8 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 8 0 0 0 0 0 0 0 8 % I
% Lys: 0 15 0 0 8 0 0 8 58 0 8 0 8 8 15 % K
% Leu: 0 8 15 58 0 0 15 0 0 8 0 0 0 8 0 % L
% Met: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 8 22 8 0 8 0 15 0 0 % N
% Pro: 0 0 0 0 0 8 0 0 0 0 0 0 0 58 8 % P
% Gln: 0 0 0 8 8 0 0 0 8 0 0 8 0 8 0 % Q
% Arg: 8 0 0 0 0 8 0 0 8 0 0 8 0 0 0 % R
% Ser: 43 0 0 0 58 0 0 43 8 8 8 50 15 8 0 % S
% Thr: 0 0 0 0 15 8 8 8 15 0 0 0 65 0 0 % T
% Val: 0 0 58 0 0 8 50 8 0 8 0 15 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 65 0 0 0 8 22 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _