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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHAF1B All Species: 30.91
Human Site: T374 Identified Species: 45.33
UniProt: Q13112 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13112 NP_005432.1 559 61493 T374 D G Y C S F V T F E K D E L G
Chimpanzee Pan troglodytes XP_525468 559 61460 T374 D G Y C S F V T F E K D E L G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544875 668 72082 S489 D G A F L A I S S T D G Y C S
Cat Felis silvestris
Mouse Mus musculus Q9D0N7 572 63114 T381 D G Y C T F V T F E K G E L G
Rat Rattus norvegicus NP_001019912 572 62715 T381 D G Y C S F V T F E K G E L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512498 575 62833 T380 D G Y C S F V T F E L G E L G
Chicken Gallus gallus Q5R1S9 566 62559 T381 D G Y C S F V T F E K D E L G
Frog Xenopus laevis Q8QFR2 1013 112021 P463 D G R R R I T P L C I A Q L D
Zebra Danio Brachydanio rerio NP_998177 236 26626 F58 D G K A V V E F L S N L A R H
Tiger Blowfish Takifugu rubipres O42611 1025 111838 K404 I E N P E M L K Y Q Q E R R N
Fruit Fly Dros. melanogaster NP_610589 747 83376 T383 D G Y C S L I T F E P T E L G
Honey Bee Apis mellifera XP_624307 452 51453 F274 V S N T T L I F S R H N L K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001191151 639 69080 T373 D G Y C S F V T F E A G E L G
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001132835 506 55177 S328 L Y V Y D T E S V P P I L V H
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_974991 487 54088 P309 E E G F F K L P Y R L V F A I
Baker's Yeast Sacchar. cerevisiae Q04199 468 51234 V290 G D E V A N C V Y V Y T R S G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 73.8 N.A. 82.3 82.6 N.A. 75.6 72.7 20.9 33.6 20.6 35.7 38.6 N.A. 44.1
Protein Similarity: 100 99.8 N.A. 76.3 N.A. 88.4 88.4 N.A. 82 81.4 33 38.4 31.7 49.6 56.1 N.A. 58.2
P-Site Identity: 100 100 N.A. 13.3 N.A. 86.6 93.3 N.A. 86.6 100 20 13.3 0 73.3 0 N.A. 86.6
P-Site Similarity: 100 100 N.A. 26.6 N.A. 93.3 93.3 N.A. 86.6 100 26.6 13.3 33.3 80 20 N.A. 86.6
Percent
Protein Identity: N.A. 37.2 N.A. 35.6 25.7 N.A.
Protein Similarity: N.A. 53.1 N.A. 54.3 42.9 N.A.
P-Site Identity: N.A. 0 N.A. 0 6.6 N.A.
P-Site Similarity: N.A. 13.3 N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 7 7 0 0 0 0 7 7 7 7 0 % A
% Cys: 0 0 0 50 0 0 7 0 0 7 0 0 0 7 0 % C
% Asp: 69 7 0 0 7 0 0 0 0 0 7 19 0 0 7 % D
% Glu: 7 13 7 0 7 0 13 0 0 50 0 7 50 0 7 % E
% Phe: 0 0 0 13 7 44 0 13 50 0 0 0 7 0 0 % F
% Gly: 7 69 7 0 0 0 0 0 0 0 0 32 0 0 57 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 13 % H
% Ile: 7 0 0 0 0 7 19 0 0 0 7 7 0 0 7 % I
% Lys: 0 0 7 0 0 7 0 7 0 0 32 0 0 7 0 % K
% Leu: 7 0 0 0 7 13 13 0 13 0 13 7 13 57 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 13 0 0 7 0 0 0 0 7 7 0 0 7 % N
% Pro: 0 0 0 7 0 0 0 13 0 7 13 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 7 0 7 0 0 % Q
% Arg: 0 0 7 7 7 0 0 0 0 13 0 0 13 13 0 % R
% Ser: 0 7 0 0 44 0 0 13 13 7 0 0 0 7 7 % S
% Thr: 0 0 0 7 13 7 7 50 0 7 0 13 0 0 0 % T
% Val: 7 0 7 7 7 7 44 7 7 7 0 7 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 50 7 0 0 0 0 19 0 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _