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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKAA1 All Species: 22.12
Human Site: S453 Identified Species: 40.56
UniProt: Q13131 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13131 NP_006242.5 559 64009 S453 R R K N P V T S T Y S K M S L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086285 574 65620 S468 R R K N P V T S T Y S K M S L
Dog Lupus familis XP_536491 563 64691 S457 R R K N P V T S T Y S K M S L
Cat Felis silvestris
Mouse Mus musculus Q5EG47 559 63911 S453 R R K N P V T S T F S K M S L
Rat Rattus norvegicus P54645 559 63955 S453 R R K N P V T S T F S K M S L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506315 519 59478 L420 S T Y S K M S L Q L Y Q V D S
Chicken Gallus gallus Q9IA88 798 88848 A620 C Q S S S S R A A R S A M S P
Frog Xenopus laevis NP_001083882 560 64031 S454 R R K N P V T S M C T K M S L
Zebra Danio Brachydanio rerio NP_001103756 573 65002 G447 R R K N P V T G M H T K M S L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623371 515 58559 D418 R S Q S K P N D I M N E V Y R
Nematode Worm Caenorhab. elegans Q95ZQ4 626 70425 A512 R K P D A P A A D P P K M S L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 Q436 T E V L K A L Q D L N V C W K
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 A534 K N L G A E W A K P S E E D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.2 92.5 N.A. 98.7 99.1 N.A. 89.2 27 88.7 84.4 N.A. N.A. 62.2 53.5 N.A.
Protein Similarity: 100 N.A. 97.3 93.7 N.A. 99.4 99.6 N.A. 91 43.1 94.6 90.9 N.A. N.A. 75.1 66.4 N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 93.3 93.3 N.A. 0 20 80 73.3 N.A. N.A. 6.6 33.3 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 100 N.A. 33.3 40 86.6 86.6 N.A. N.A. 40 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 45 33.4 N.A.
Protein Similarity: N.A. N.A. N.A. 62.4 51.9 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 16 8 8 24 8 0 0 8 0 0 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % C
% Asp: 0 0 0 8 0 0 0 8 16 0 0 0 0 16 0 % D
% Glu: 0 8 0 0 0 8 0 0 0 0 0 16 8 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % I
% Lys: 8 8 54 0 24 0 0 0 8 0 0 62 0 0 8 % K
% Leu: 0 0 8 8 0 0 8 8 0 16 0 0 0 0 70 % L
% Met: 0 0 0 0 0 8 0 0 16 8 0 0 70 0 0 % M
% Asn: 0 8 0 54 0 0 8 0 0 0 16 0 0 0 0 % N
% Pro: 0 0 8 0 54 16 0 0 0 16 8 0 0 0 8 % P
% Gln: 0 8 8 0 0 0 0 8 8 0 0 8 0 0 0 % Q
% Arg: 70 54 0 0 0 0 8 0 0 8 0 0 0 0 8 % R
% Ser: 8 8 8 24 8 8 8 47 0 0 54 0 0 70 8 % S
% Thr: 8 8 0 0 0 0 54 0 39 0 16 0 0 0 0 % T
% Val: 0 0 8 0 0 54 0 0 0 0 0 8 16 0 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 24 8 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _