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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKAA1 All Species: 21.21
Human Site: T522 Identified Species: 38.89
UniProt: Q13131 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13131 NP_006242.5 559 64009 T522 K S S E V S L T S S V T S L D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086285 574 65620 T537 K S S E V S L T S S V T S L D
Dog Lupus familis XP_536491 563 64691 T526 K S S E A S L T S S V T S L D
Cat Felis silvestris
Mouse Mus musculus Q5EG47 559 63911 T522 K P S D V S L T S S V T S L D
Rat Rattus norvegicus P54645 559 63955 T522 K P S E V S L T S S V T S L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506315 519 59478 E489 T S S V T S L E S P T A D L T
Chicken Gallus gallus Q9IA88 798 88848 D689 T N G L P P S D S A G T C K A
Frog Xenopus laevis NP_001083882 560 64031 S523 S S D G S G P S S L T S S V D
Zebra Danio Brachydanio rerio NP_001103756 573 65002 A516 E D A A K G E A S A P S T P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623371 515 58559 P487 E E D I G R D P T I L P P Q T
Nematode Worm Caenorhab. elegans Q95ZQ4 626 70425 I581 A M S M E A S I E K M E V H D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38997 535 61163 D505 Q L Y K T R D D K Y L L D L Q
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 S603 D T T V S N I S E D E M S T F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 97.2 92.5 N.A. 98.7 99.1 N.A. 89.2 27 88.7 84.4 N.A. N.A. 62.2 53.5 N.A.
Protein Similarity: 100 N.A. 97.3 93.7 N.A. 99.4 99.6 N.A. 91 43.1 94.6 90.9 N.A. N.A. 75.1 66.4 N.A.
P-Site Identity: 100 N.A. 100 93.3 N.A. 86.6 93.3 N.A. 40 13.3 26.6 6.6 N.A. N.A. 0 13.3 N.A.
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 93.3 N.A. 40 26.6 46.6 40 N.A. N.A. 20 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 45 33.4 N.A.
Protein Similarity: N.A. N.A. N.A. 62.4 51.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 8 8 0 8 0 16 0 8 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 8 16 8 0 0 16 16 0 8 0 0 16 0 54 % D
% Glu: 16 8 0 31 8 0 8 8 16 0 8 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 8 8 8 16 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 8 0 0 8 8 0 8 0 0 0 0 0 % I
% Lys: 39 0 0 8 8 0 0 0 8 8 0 0 0 8 0 % K
% Leu: 0 8 0 8 0 0 47 0 0 8 16 8 0 54 0 % L
% Met: 0 8 0 8 0 0 0 0 0 0 8 8 0 0 0 % M
% Asn: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 16 0 0 8 8 8 8 0 8 8 8 8 8 8 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 8 % Q
% Arg: 0 0 0 0 0 16 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 39 54 0 16 47 16 16 70 39 0 16 54 0 0 % S
% Thr: 16 8 8 0 16 0 0 39 8 0 16 47 8 8 16 % T
% Val: 0 0 0 16 31 0 0 0 0 0 39 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _