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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NR1H3 All Species: 35.45
Human Site: S170 Identified Species: 60
UniProt: Q13133 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13133 NP_001123573.1 447 50396 S170 M R E E C V L S E E Q I R L K
Chimpanzee Pan troglodytes XP_001168389 511 57483 S170 M R E E C V L S E E Q I R L K
Rhesus Macaque Macaca mulatta XP_001108843 447 50535 S170 M R E E C V L S E E Q I R L K
Dog Lupus familis XP_540745 447 50216 S170 M R E E C V L S E E Q I R L K
Cat Felis silvestris
Mouse Mus musculus Q9Z0Y9 445 50458 S168 M R E E C V L S E E Q I R L K
Rat Rattus norvegicus Q62685 445 50536 S168 M R E E C V L S E E Q I R L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517956 624 68359 S347 M R E Q C V L S E E Q I R L K
Chicken Gallus gallus O42392 451 51281 N174 D T T Y S D F N K F R P P V R
Frog Xenopus laevis P51126 458 50544 S154 K C F E V G M S K E S V R N D
Zebra Danio Brachydanio rerio Q9PTN2 453 50848 S157 E A R K P R L S D E Q M Q I I
Tiger Blowfish Takifugu rubipres Q9W5Z3 447 49514 N155 E S V R N D R N K K K K D E K
Fruit Fly Dros. melanogaster P34021 878 93835 P336 M R P E C V V P E N Q C A M K
Honey Bee Apis mellifera NP_001091685 629 66768 P321 M R P E C V V P E Y Q C A V K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001123279 490 55735 T169 M L A E C L L T E E Q C K S K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 97.7 92.1 N.A. 91.7 91.2 N.A. 61.8 24.1 31.6 25.1 32.2 23.3 30.3 N.A. 38.7
Protein Similarity: 100 87.4 98.4 94.1 N.A. 94.4 93.9 N.A. 65 40.1 47.1 45.7 50.1 33.7 45.9 N.A. 57.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 0 26.6 26.6 6.6 53.3 53.3 N.A. 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 33.3 46.6 60 33.3 66.6 66.6 N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 0 0 0 0 0 0 0 15 0 0 % A
% Cys: 0 8 0 0 72 0 0 0 0 0 0 22 0 0 0 % C
% Asp: 8 0 0 0 0 15 0 0 8 0 0 0 8 0 8 % D
% Glu: 15 0 50 72 0 0 0 0 72 72 0 0 0 8 0 % E
% Phe: 0 0 8 0 0 0 8 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 50 0 8 8 % I
% Lys: 8 0 0 8 0 0 0 0 22 8 8 8 8 0 79 % K
% Leu: 0 8 0 0 0 8 65 0 0 0 0 0 0 50 0 % L
% Met: 72 0 0 0 0 0 8 0 0 0 0 8 0 8 0 % M
% Asn: 0 0 0 0 8 0 0 15 0 8 0 0 0 8 0 % N
% Pro: 0 0 15 0 8 0 0 15 0 0 0 8 8 0 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 79 0 8 0 0 % Q
% Arg: 0 65 8 8 0 8 8 0 0 0 8 0 58 0 8 % R
% Ser: 0 8 0 0 8 0 0 65 0 0 8 0 0 8 0 % S
% Thr: 0 8 8 0 0 0 0 8 0 0 0 0 0 0 0 % T
% Val: 0 0 8 0 8 65 15 0 0 0 0 8 0 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _