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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NR1H3 All Species: 24.85
Human Site: S191 Identified Species: 42.05
UniProt: Q13133 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13133 NP_001123573.1 447 50396 S191 E E Q A H A T S L P P R A S S
Chimpanzee Pan troglodytes XP_001168389 511 57483 S191 E E Q A H A T S L P P R A S S
Rhesus Macaque Macaca mulatta XP_001108843 447 50535 S191 E E Q A H A I S L P P R A S S
Dog Lupus familis XP_540745 447 50216 S191 E E Q A Q A T S M P P R V S S
Cat Felis silvestris
Mouse Mus musculus Q9Z0Y9 445 50458 S189 E E Q A Q A T S V S P R V S S
Rat Rattus norvegicus Q62685 445 50536 S189 E E Q A Q A T S V S P R V S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517956 624 68359 P368 E E Q A Q A A P P P P Q A S L
Chicken Gallus gallus O42392 451 51281 S194 R M A T H S S S V V S Q D F S
Frog Xenopus laevis P51126 458 50544 K171 K K K K E S P K P E A I E S Y
Zebra Danio Brachydanio rerio Q9PTN2 453 50848 F182 Y D D S Y S D F V R F R P P V
Tiger Blowfish Takifugu rubipres Q9W5Z3 447 49514 V171 P E C I E N Y V L S P D T E Q
Fruit Fly Dros. melanogaster P34021 878 93835 C389 E I L D L M T C E P P Q H A T
Honey Bee Apis mellifera NP_001091685 629 66768 T345 K D K P N S T T M N G S P G S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001123279 490 55735 I217 V I E N L V S I H K E L E I P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 97.7 92.1 N.A. 91.7 91.2 N.A. 61.8 24.1 31.6 25.1 32.2 23.3 30.3 N.A. 38.7
Protein Similarity: 100 87.4 98.4 94.1 N.A. 94.4 93.9 N.A. 65 40.1 47.1 45.7 50.1 33.7 45.9 N.A. 57.9
P-Site Identity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 60 20 6.6 6.6 20 26.6 13.3 N.A. 0
P-Site Similarity: 100 100 93.3 86.6 N.A. 80 80 N.A. 66.6 46.6 33.3 40 20 46.6 60 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 50 0 50 8 0 0 0 8 0 29 8 0 % A
% Cys: 0 0 8 0 0 0 0 8 0 0 0 0 0 0 0 % C
% Asp: 0 15 8 8 0 0 8 0 0 0 0 8 8 0 0 % D
% Glu: 58 58 8 0 15 0 0 0 8 8 8 0 15 8 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 8 0 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % G
% His: 0 0 0 0 29 0 0 0 8 0 0 0 8 0 0 % H
% Ile: 0 15 0 8 0 0 8 8 0 0 0 8 0 8 0 % I
% Lys: 15 8 15 8 0 0 0 8 0 8 0 0 0 0 0 % K
% Leu: 0 0 8 0 15 0 0 0 29 0 0 8 0 0 8 % L
% Met: 0 8 0 0 0 8 0 0 15 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 8 8 0 0 0 8 0 0 0 0 0 % N
% Pro: 8 0 0 8 0 0 8 8 15 43 65 0 15 8 8 % P
% Gln: 0 0 50 0 29 0 0 0 0 0 0 22 0 0 8 % Q
% Arg: 8 0 0 0 0 0 0 0 0 8 0 50 0 0 0 % R
% Ser: 0 0 0 8 0 29 15 50 0 22 8 8 0 58 58 % S
% Thr: 0 0 0 8 0 0 50 8 0 0 0 0 8 0 8 % T
% Val: 8 0 0 0 0 8 0 8 29 8 0 0 22 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 8 0 8 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _