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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H3
All Species:
29.39
Human Site:
S228
Identified Species:
49.74
UniProt:
Q13133
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13133
NP_001123573.1
447
50396
S228
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Chimpanzee
Pan troglodytes
XP_001168389
511
57483
S228
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Rhesus Macaque
Macaca mulatta
XP_001108843
447
50535
S228
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Dog
Lupus familis
XP_540745
447
50216
S228
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0Y9
445
50458
S226
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Rat
Rattus norvegicus
Q62685
445
50536
S226
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
S405
Q
Q
L
C
N
R
R
S
F
S
D
Q
L
R
V
Chicken
Gallus gallus
O42392
451
51281
M225
P
E
P
M
E
P
Q
M
F
S
N
L
D
L
S
Frog
Xenopus laevis
P51126
458
50544
L202
H
Q
E
T
F
P
A
L
C
Q
L
G
K
Y
T
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
N227
E
S
V
D
T
K
L
N
F
S
N
L
L
M
M
Tiger Blowfish
Takifugu rubipres
Q9W5Z3
447
49514
T203
Q
L
G
K
Y
T
T
T
N
S
S
E
R
R
V
Fruit Fly
Dros. melanogaster
P34021
878
93835
Y434
L
I
W
Y
Q
D
G
Y
E
Q
P
S
E
E
D
Honey Bee
Apis mellifera
NP_001091685
629
66768
Y411
L
V
Y
F
Q
N
E
Y
E
Q
P
S
E
E
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
S273
L
P
G
L
M
P
V
S
L
T
P
K
R
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
97.7
92.1
N.A.
91.7
91.2
N.A.
61.8
24.1
31.6
25.1
32.2
23.3
30.3
N.A.
38.7
Protein Similarity:
100
87.4
98.4
94.1
N.A.
94.4
93.9
N.A.
65
40.1
47.1
45.7
50.1
33.7
45.9
N.A.
57.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
86.6
13.3
6.6
20
26.6
0
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
33.3
13.3
53.3
33.3
0
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
50
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
8
0
0
0
0
50
0
8
0
15
% D
% Glu:
8
8
8
0
8
0
8
0
15
0
0
8
15
15
8
% E
% Phe:
0
0
0
8
8
0
0
0
65
0
0
0
0
0
0
% F
% Gly:
0
0
15
0
0
0
8
0
0
0
0
8
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
8
0
0
0
0
0
8
8
0
0
% K
% Leu:
22
8
8
8
0
0
8
8
8
0
8
15
58
8
0
% L
% Met:
0
0
0
8
8
0
0
8
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
0
50
8
0
8
8
0
15
0
0
0
0
% N
% Pro:
8
8
8
0
0
22
0
0
0
0
22
0
0
0
0
% P
% Gln:
58
58
43
0
15
0
8
0
0
22
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
50
50
0
0
0
0
43
15
58
0
% R
% Ser:
0
8
0
0
0
0
0
58
0
72
8
15
0
8
8
% S
% Thr:
0
0
0
8
8
8
8
8
0
8
0
0
0
0
8
% T
% Val:
0
8
8
0
0
0
8
0
0
0
0
0
0
0
58
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
8
0
0
15
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _