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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H3
All Species:
40
Human Site:
S422
Identified Species:
67.69
UniProt:
Q13133
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13133
NP_001123573.1
447
50396
S422
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Chimpanzee
Pan troglodytes
XP_001168389
511
57483
S486
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Rhesus Macaque
Macaca mulatta
XP_001108843
447
50535
S422
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Dog
Lupus familis
XP_540745
447
50216
S422
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0Y9
445
50458
S420
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Rat
Rattus norvegicus
Q62685
445
50536
S420
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
S599
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Chicken
Gallus gallus
O42392
451
51281
S422
R
S
L
N
E
E
H
S
K
Q
Y
R
C
L
S
Frog
Xenopus laevis
P51126
458
50544
A392
R
T
V
S
A
K
G
A
E
R
V
I
T
L
K
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
S424
R
S
L
N
E
E
H
S
K
Q
Y
R
S
L
S
Tiger Blowfish
Takifugu rubipres
Q9W5Z3
447
49514
A384
R
S
I
S
A
K
G
A
E
R
V
I
T
L
K
Fruit Fly
Dros. melanogaster
P34021
878
93835
A629
R
T
L
G
N
Q
N
A
E
M
C
F
S
L
K
Honey Bee
Apis mellifera
NP_001091685
629
66768
S604
R
T
L
G
N
Q
N
S
E
M
C
F
S
L
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
S466
R
S
L
N
N
S
H
S
E
L
L
F
Q
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
97.7
92.1
N.A.
91.7
91.2
N.A.
61.8
24.1
31.6
25.1
32.2
23.3
30.3
N.A.
38.7
Protein Similarity:
100
87.4
98.4
94.1
N.A.
94.4
93.9
N.A.
65
40.1
47.1
45.7
50.1
33.7
45.9
N.A.
57.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
40
40
40
33.3
40
46.6
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
60
73.3
66.6
73.3
73.3
73.3
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
15
0
0
22
0
0
0
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
15
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
15
15
0
0
86
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
72
0
0
0
% F
% Gly:
0
0
0
15
0
0
15
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
72
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
15
0
0
0
% I
% Lys:
0
0
0
0
0
15
0
0
15
0
0
0
0
0
36
% K
% Leu:
0
0
86
0
0
0
0
0
0
8
8
0
0
100
0
% L
% Met:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% M
% Asn:
0
0
0
22
22
0
15
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
15
0
0
0
65
0
0
8
0
0
% Q
% Arg:
100
0
0
0
0
0
0
0
0
15
0
15
0
0
50
% R
% Ser:
0
29
0
65
50
8
0
79
0
0
0
0
22
0
15
% S
% Thr:
0
72
0
0
0
0
0
0
0
0
0
0
15
0
0
% T
% Val:
0
0
8
0
0
50
0
0
0
0
65
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
15
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _