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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H3
All Species:
27.27
Human Site:
S440
Identified Species:
46.15
UniProt:
Q13133
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13133
NP_001123573.1
447
50396
S440
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Chimpanzee
Pan troglodytes
XP_001168389
511
57483
S504
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Rhesus Macaque
Macaca mulatta
XP_001108843
447
50535
S440
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Dog
Lupus familis
XP_540745
447
50216
S440
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0Y9
445
50458
S438
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Rat
Rattus norvegicus
Q62685
445
50536
S438
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
S617
K
K
L
P
P
L
L
S
E
I
W
D
V
H
D
Chicken
Gallus gallus
O42392
451
51281
L443
M
Q
L
T
P
L
V
L
E
V
F
G
N
E
I
Frog
Xenopus laevis
P51126
458
50544
P407
M
E
I
P
G
A
M
P
L
I
Q
E
M
L
E
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
L445
M
Q
L
T
P
L
V
L
E
V
F
G
S
E
V
Tiger Blowfish
Takifugu rubipres
Q9W5Z3
447
49514
Q403
G
S
M
P
P
L
I
Q
E
M
L
E
N
S
E
Fruit Fly
Dros. melanogaster
P34021
878
93835
E647
R
K
L
P
K
F
L
E
E
I
W
D
V
H
A
Honey Bee
Apis mellifera
NP_001091685
629
66768
A622
K
K
L
P
V
F
L
A
E
I
W
D
V
T
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
97.7
92.1
N.A.
91.7
91.2
N.A.
61.8
24.1
31.6
25.1
32.2
23.3
30.3
N.A.
38.7
Protein Similarity:
100
87.4
98.4
94.1
N.A.
94.4
93.9
N.A.
65
40.1
47.1
45.7
50.1
33.7
45.9
N.A.
57.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
26.6
20
26.6
33.3
66.6
66.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
53.3
53.3
53.3
60
73.3
73.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
65
0
0
8
% D
% Glu:
0
8
0
0
0
0
0
8
86
0
0
15
0
15
58
% E
% Phe:
0
0
0
0
0
15
0
0
0
0
15
0
0
0
0
% F
% Gly:
8
0
0
0
8
0
0
0
0
0
0
15
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
58
0
% H
% Ile:
0
0
8
0
0
0
8
0
0
72
0
0
0
0
8
% I
% Lys:
58
65
0
0
8
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
79
0
0
72
65
15
8
0
8
0
0
8
0
% L
% Met:
22
0
8
0
0
0
8
0
0
8
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% N
% Pro:
0
0
0
79
72
0
0
8
0
0
0
0
0
0
8
% P
% Gln:
0
15
0
0
0
0
0
8
0
0
8
0
0
0
0
% Q
% Arg:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
50
0
0
0
0
8
8
0
% S
% Thr:
0
0
0
15
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
8
0
15
0
0
15
0
0
65
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
65
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _