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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B5
All Species:
31.82
Human Site:
S686
Identified Species:
58.33
UniProt:
Q13144
Number Species:
12
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13144
NP_003898.2
721
80380
S686
E
T
I
L
S
W
F
S
Q
R
D
T
T
D
K
Chimpanzee
Pan troglodytes
XP_001139517
721
80405
S686
E
T
I
L
S
W
F
S
Q
R
D
T
T
D
K
Rhesus Macaque
Macaca mulatta
XP_001104122
721
80584
S686
E
T
I
L
S
W
F
S
Q
R
D
T
T
D
K
Dog
Lupus familis
XP_545227
721
80416
S686
E
T
I
L
S
W
F
S
Q
K
D
M
T
D
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHW4
717
80068
S682
E
T
I
L
S
W
F
S
Q
R
D
T
T
D
E
Rat
Rattus norvegicus
Q64350
716
80188
S681
E
T
I
L
S
W
F
S
Q
R
D
I
T
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506973
657
73984
D626
F
C
Q
K
D
T
T
D
K
G
R
Q
L
R
K
Chicken
Gallus gallus
XP_422755
716
81293
S670
D
V
I
L
N
W
F
S
L
R
D
T
S
D
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107069
703
79791
T669
D
V
I
M
R
W
F
T
Q
S
S
T
T
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784928
1190
133261
S1154
E
V
I
L
K
W
Y
S
K
M
D
Q
D
A
D
Poplar Tree
Populus trichocarpa
XP_002328528
718
80680
D687
D
A
I
L
R
W
A
D
E
K
K
D
A
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_181042
730
81845
E687
D
A
I
L
R
W
E
E
E
K
A
G
A
D
E
Baker's Yeast
Sacchar. cerevisiae
P32501
712
81143
D678
D
V
I
Y
K
W
W
D
N
V
S
T
D
P
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
93.1
N.A.
88.3
88.3
N.A.
77.2
73.2
N.A.
62.9
N.A.
N.A.
N.A.
N.A.
27.2
Protein Similarity:
100
99.8
99
96.2
N.A.
93.4
93.9
N.A.
83.7
85.3
N.A.
78.5
N.A.
N.A.
N.A.
N.A.
40
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
6.6
66.6
N.A.
53.3
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
100
100
93.3
N.A.
100
93.3
N.A.
13.3
86.6
N.A.
73.3
N.A.
N.A.
N.A.
N.A.
53.3
Percent
Protein Identity:
33.8
N.A.
N.A.
32.7
28.8
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.2
50
N.A.
P-Site Identity:
20
N.A.
N.A.
26.6
20
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
53.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
0
8
0
0
0
8
0
16
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
39
0
0
0
8
0
0
24
0
0
62
8
16
70
8
% D
% Glu:
54
0
0
0
0
0
8
8
16
0
0
0
0
8
24
% E
% Phe:
8
0
0
0
0
0
62
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
93
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
8
16
0
0
0
16
24
8
0
0
0
62
% K
% Leu:
0
0
0
77
0
0
0
0
8
0
0
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
8
0
8
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
54
0
0
16
0
0
0
% Q
% Arg:
0
0
0
0
24
0
0
0
0
47
8
0
0
8
8
% R
% Ser:
0
0
0
0
47
0
0
62
0
8
16
0
8
0
0
% S
% Thr:
0
47
0
0
0
8
8
8
0
0
0
54
54
0
0
% T
% Val:
0
31
0
0
0
0
0
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
93
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _