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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B5
All Species:
36.13
Human Site:
S718
Identified Species:
66.24
UniProt:
Q13144
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13144
NP_003898.2
721
80380
S718
K
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001139517
721
80405
S718
K
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001104122
721
80584
S718
K
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Dog
Lupus familis
XP_545227
721
80416
S718
K
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
Q8CHW4
717
80068
S714
R
E
A
E
E
E
S
S
E
D
D
_
_
_
_
Rat
Rattus norvegicus
Q64350
716
80188
S713
R
E
A
E
E
E
S
S
D
D
D
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506973
657
73984
S652
K
E
A
E
E
E
S
S
E
E
D
R
D
_
_
Chicken
Gallus gallus
XP_422755
716
81293
S711
E
E
A
E
E
E
S
S
D
G
D
Q
D
_
_
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001107069
703
79791
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784928
1190
133261
D1186
Q
E
A
E
E
E
S
D
E
E
S
D
_
_
_
Poplar Tree
Populus trichocarpa
XP_002328528
718
80680
S714
I
Q
W
L
R
E
A
S
E
E
E
D
_
_
_
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_181042
730
81845
D718
K
E
A
S
E
E
E
D
E
D
D
E
D
E
E
Baker's Yeast
Sacchar. cerevisiae
P32501
712
81143
S708
Q
N
A
D
E
E
S
S
S
E
E
E
_
_
_
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.3
93.1
N.A.
88.3
88.3
N.A.
77.2
73.2
N.A.
62.9
N.A.
N.A.
N.A.
N.A.
27.2
Protein Similarity:
100
99.8
99
96.2
N.A.
93.4
93.9
N.A.
83.7
85.3
N.A.
78.5
N.A.
N.A.
N.A.
N.A.
40
P-Site Identity:
100
100
100
100
N.A.
90.9
81.8
N.A.
76.9
61.5
N.A.
0
N.A.
N.A.
N.A.
N.A.
58.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
84.6
76.9
N.A.
0
N.A.
N.A.
N.A.
N.A.
75
Percent
Protein Identity:
33.8
N.A.
N.A.
32.7
28.8
N.A.
Protein Similarity:
55.2
N.A.
N.A.
53.2
50
N.A.
P-Site Identity:
25
N.A.
N.A.
53.3
41.6
N.A.
P-Site Similarity:
58.3
N.A.
N.A.
53.3
75
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
85
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
16
16
54
70
16
24
0
0
% D
% Glu:
8
77
0
70
85
93
8
0
70
31
16
16
0
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
47
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
16
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
16
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
8
0
0
77
77
8
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
47
70
85
85
% _