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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B5 All Species: 15.15
Human Site: T424 Identified Species: 27.78
UniProt: Q13144 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13144 NP_003898.2 721 80380 T424 A E V K E R V T L K P R S V L
Chimpanzee Pan troglodytes XP_001139517 721 80405 T424 A E V K E R V T L K P R C V L
Rhesus Macaque Macaca mulatta XP_001104122 721 80584 T424 A E V K E R V T L K P R C V L
Dog Lupus familis XP_545227 721 80416 T424 A E V K E Q V T L K P R C V L
Cat Felis silvestris
Mouse Mus musculus Q8CHW4 717 80068 K420 A E V K E R V K L K P Y C V L
Rat Rattus norvegicus Q64350 716 80188 I419 A E V K E R V I L K P H C V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506973 657 73984 E392 L H P P D A E E D E D D D Q F
Chicken Gallus gallus XP_422755 716 81293 K410 A E V K E K V K L K P H C V L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001107069 703 79791 V406 V E V K H G V V L N E Q C V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784928 1190 133261 T885 V H V K S E V T I K N G C V L
Poplar Tree Populus trichocarpa XP_002328528 718 80680 A405 V V I K S G A A L E P G V V L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_181042 730 81845 V411 V K I R A G A V L Q P G V V L
Baker's Yeast Sacchar. cerevisiae P32501 712 81143 R407 A T L G S N V R L N D G C I I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.3 93.1 N.A. 88.3 88.3 N.A. 77.2 73.2 N.A. 62.9 N.A. N.A. N.A. N.A. 27.2
Protein Similarity: 100 99.8 99 96.2 N.A. 93.4 93.9 N.A. 83.7 85.3 N.A. 78.5 N.A. N.A. N.A. N.A. 40
P-Site Identity: 100 93.3 93.3 86.6 N.A. 80 80 N.A. 0 73.3 N.A. 46.6 N.A. N.A. N.A. N.A. 46.6
P-Site Similarity: 100 93.3 93.3 93.3 N.A. 80 80 N.A. 13.3 80 N.A. 53.3 N.A. N.A. N.A. N.A. 53.3
Percent
Protein Identity: 33.8 N.A. N.A. 32.7 28.8 N.A.
Protein Similarity: 55.2 N.A. N.A. 53.2 50 N.A.
P-Site Identity: 33.3 N.A. N.A. 26.6 20 N.A.
P-Site Similarity: 46.6 N.A. N.A. 53.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 62 0 0 0 8 8 16 8 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 70 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 8 0 16 8 8 0 0 % D
% Glu: 0 62 0 0 54 8 8 8 0 16 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 8 0 24 0 0 0 0 0 31 0 0 0 % G
% His: 0 16 0 0 8 0 0 0 0 0 0 16 0 0 0 % H
% Ile: 0 0 16 0 0 0 0 8 8 0 0 0 0 8 8 % I
% Lys: 0 8 0 77 0 8 0 16 0 62 0 0 0 0 0 % K
% Leu: 8 0 8 0 0 0 0 0 85 0 0 0 0 0 85 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 0 0 16 8 0 0 0 0 % N
% Pro: 0 0 8 8 0 0 0 0 0 0 70 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 8 0 8 0 8 0 % Q
% Arg: 0 0 0 8 0 39 0 8 0 0 0 31 0 0 0 % R
% Ser: 0 0 0 0 24 0 0 0 0 0 0 0 8 0 0 % S
% Thr: 0 8 0 0 0 0 0 39 0 0 0 0 0 0 0 % T
% Val: 31 8 70 0 0 0 77 16 0 0 0 0 16 85 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _