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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK1
All Species:
26.06
Human Site:
S223
Identified Species:
44.1
UniProt:
Q13153
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13153
NP_001122092.1
545
60647
S223
D
V
A
T
S
P
I
S
P
T
E
N
N
T
T
Chimpanzee
Pan troglodytes
XP_508657
536
59744
S223
D
V
A
T
S
P
I
S
P
T
E
N
N
T
T
Rhesus Macaque
Macaca mulatta
XP_001090077
545
60664
S223
D
V
A
T
S
P
I
S
P
T
E
N
N
T
T
Dog
Lupus familis
XP_849651
544
60649
S222
D
A
A
T
S
P
I
S
P
T
E
N
N
T
T
Cat
Felis silvestris
Mouse
Mus musculus
O88643
545
60718
S223
D
V
A
T
S
P
I
S
P
T
E
N
N
T
T
Rat
Rattus norvegicus
P35465
544
60559
S222
D
V
A
T
S
P
I
S
P
T
E
N
N
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509462
527
58159
R223
I
V
S
P
C
P
L
R
G
S
Q
R
K
E
N
Chicken
Gallus gallus
NP_001155844
544
60631
S222
V
A
T
S
P
I
S
S
P
S
E
N
S
T
A
Frog
Xenopus laevis
NP_001079232
564
62749
P241
A
S
T
S
P
V
T
P
Q
P
E
N
S
N
S
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
I222
K
D
A
A
T
S
P
I
T
N
A
A
A
D
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
G321
R
A
S
S
S
S
G
G
A
S
S
A
A
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
E248
I
Y
T
K
P
K
E
E
E
E
K
I
P
D
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
T573
P
A
Q
E
T
V
T
T
P
T
S
K
P
A
Q
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
G627
P
R
Q
P
D
I
N
G
A
P
R
M
P
Q
T
Conservation
Percent
Protein Identity:
100
94.3
99.6
96.6
N.A.
97.6
98.9
N.A.
78.7
94.5
80.6
81.9
N.A.
32.7
N.A.
54.7
N.A.
Protein Similarity:
100
95.2
99.6
97
N.A.
98.7
99
N.A.
85.3
96.8
88.3
87.8
N.A.
50.8
N.A.
68.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
13.3
33.3
13.3
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
40
53.3
33.3
13.3
N.A.
26.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.5
32.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.6
43.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
29
50
8
0
0
0
0
15
0
8
15
15
8
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
43
8
0
0
8
0
0
0
0
0
0
0
0
15
0
% D
% Glu:
0
0
0
8
0
0
8
8
8
8
58
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
8
15
8
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
0
0
15
43
8
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
8
0
8
0
0
0
0
8
8
8
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
58
43
8
8
% N
% Pro:
15
0
0
15
22
50
8
8
58
15
0
0
22
0
0
% P
% Gln:
0
0
15
0
0
0
0
0
8
0
8
0
0
15
15
% Q
% Arg:
8
8
0
0
0
0
0
8
0
0
8
8
0
0
0
% R
% Ser:
0
8
15
22
50
15
8
50
0
22
15
0
15
0
8
% S
% Thr:
0
0
22
43
15
0
15
8
8
50
0
0
0
50
50
% T
% Val:
8
43
0
0
0
15
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _