KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PAK1
All Species:
27.27
Human Site:
T185
Identified Species:
46.15
UniProt:
Q13153
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13153
NP_001122092.1
545
60647
T185
D
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Chimpanzee
Pan troglodytes
XP_508657
536
59744
T185
D
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Rhesus Macaque
Macaca mulatta
XP_001090077
545
60664
T185
D
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Dog
Lupus familis
XP_849651
544
60649
T184
E
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Cat
Felis silvestris
Mouse
Mus musculus
O88643
545
60718
T185
E
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Rat
Rattus norvegicus
P35465
544
60559
T184
E
D
D
D
D
D
A
T
P
P
P
V
I
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509462
527
58159
G185
S
L
G
D
P
P
V
G
G
P
R
S
R
R
R
Chicken
Gallus gallus
NP_001155844
544
60631
A184
E
D
D
E
D
D
A
A
P
P
P
V
I
A
P
Frog
Xenopus laevis
NP_001079232
564
62749
P203
E
E
D
D
N
E
P
P
P
V
I
A
P
R
P
Zebra Danio
Brachydanio rerio
NP_958485
577
63243
T184
D
E
E
E
D
E
A
T
P
P
P
V
I
A
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VXE5
639
69601
A283
Q
Q
Q
Q
Q
Q
Q
A
K
Q
G
G
D
Q
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17850
572
63863
P210
E
N
R
S
S
M
P
P
S
Y
A
P
P
P
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03497
939
102344
P535
T
L
K
K
E
E
Q
P
L
P
P
I
P
P
T
Red Bread Mold
Neurospora crassa
Q7RZD3
954
103773
M589
Q
H
Q
Q
E
Q
A
M
A
Q
A
Q
A
A
M
Conservation
Percent
Protein Identity:
100
94.3
99.6
96.6
N.A.
97.6
98.9
N.A.
78.7
94.5
80.6
81.9
N.A.
32.7
N.A.
54.7
N.A.
Protein Similarity:
100
95.2
99.6
97
N.A.
98.7
99
N.A.
85.3
96.8
88.3
87.8
N.A.
50.8
N.A.
68.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
13.3
80
26.6
73.3
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
53.3
100
N.A.
0
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32.5
32.7
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
43.6
43.8
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
65
15
8
0
15
8
8
65
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
29
50
58
58
58
50
0
0
0
0
0
0
8
0
0
% D
% Glu:
43
15
8
15
15
22
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
8
8
0
8
8
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
8
58
0
0
% I
% Lys:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
15
0
0
0
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
8
% M
% Asn:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
8
8
15
22
65
72
65
8
22
15
65
% P
% Gln:
15
8
15
15
8
15
15
0
0
15
0
8
0
8
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
8
0
8
15
8
% R
% Ser:
8
0
0
8
8
0
0
0
8
0
0
8
0
0
0
% S
% Thr:
8
0
0
0
0
0
0
50
0
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
0
0
8
0
58
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _