KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K5
All Species:
21.52
Human Site:
S142
Identified Species:
33.81
UniProt:
Q13163
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13163
NP_002748.1
448
50112
S142
A
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Chimpanzee
Pan troglodytes
XP_001174798
467
51808
S142
A
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Rhesus Macaque
Macaca mulatta
XP_001111645
449
50213
S142
A
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Dog
Lupus familis
XP_852868
288
32448
T11
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVS7
448
50086
S142
V
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Rat
Rattus norvegicus
Q62862
448
50179
S142
V
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516129
399
44778
K97
S
L
P
G
N
S
L
K
K
S
S
A
E
L
K
Chicken
Gallus gallus
NP_001073184
351
39168
E74
S
L
K
K
S
S
A
E
L
K
K
I
L
A
N
Frog
Xenopus laevis
NP_001084729
448
49926
S142
S
V
P
D
N
I
S
S
N
C
L
K
K
S
S
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
G84
A
D
D
L
E
Q
I
G
E
L
G
R
G
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
I112
R
H
T
H
T
H
L
I
M
A
R
K
L
I
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
L103
G
V
I
M
A
R
K
L
V
H
L
E
I
K
P
Sea Urchin
Strong. purpuratus
XP_786275
385
43129
V96
P
L
N
I
Y
P
Q
V
K
P
G
G
R
K
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
G77
V
I
K
V
I
G
K
G
S
S
G
N
V
Q
L
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Q215
A
I
I
N
T
P
K
Q
S
L
S
A
R
R
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
99.5
63.3
N.A.
97.7
98.2
N.A.
82.3
74.1
84.8
30.5
N.A.
35
N.A.
37
49.3
Protein Similarity:
100
93.3
99.5
64.2
N.A.
99.1
99.1
N.A.
86.1
76.1
89.9
47.3
N.A.
54.2
N.A.
53.7
63.1
P-Site Identity:
100
100
100
0
N.A.
93.3
93.3
N.A.
6.6
6.6
60
6.6
N.A.
6.6
N.A.
13.3
0
P-Site Similarity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
33.3
33.3
80
20
N.A.
26.6
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.5
42.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
0
0
0
7
0
7
0
0
7
0
14
0
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
14
7
40
0
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
7
0
0
7
7
0
0
7
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
7
0
7
0
14
0
7
20
14
7
7
7
% G
% His:
0
7
0
7
0
7
0
0
0
7
7
0
0
0
7
% H
% Ile:
0
14
20
7
7
7
7
7
0
0
0
7
7
7
0
% I
% Lys:
0
0
14
7
0
0
20
7
14
7
7
47
40
14
7
% K
% Leu:
0
20
0
7
0
34
14
7
14
14
47
0
14
7
7
% L
% Met:
0
0
0
7
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
14
0
0
0
40
0
0
7
7
0
14
% N
% Pro:
7
0
14
0
0
14
34
0
0
7
0
0
0
0
7
% P
% Gln:
7
0
0
0
0
7
7
7
0
0
0
0
0
7
0
% Q
% Arg:
7
0
0
7
0
14
0
0
0
0
7
7
14
7
0
% R
% Ser:
20
0
34
0
40
14
7
40
14
47
14
0
0
40
40
% S
% Thr:
0
0
7
0
14
0
0
7
0
0
0
0
0
0
0
% T
% Val:
20
47
0
7
0
0
0
7
7
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
14
0
0
0
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _