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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K5 All Species: 21.52
Human Site: S142 Identified Species: 33.81
UniProt: Q13163 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13163 NP_002748.1 448 50112 S142 A V S D S L P S N S L K K S S
Chimpanzee Pan troglodytes XP_001174798 467 51808 S142 A V S D S L P S N S L K K S S
Rhesus Macaque Macaca mulatta XP_001111645 449 50213 S142 A V S D S L P S N S L K K S S
Dog Lupus familis XP_852868 288 32448 T11 Q D I R Y R D T L G H G N G G
Cat Felis silvestris
Mouse Mus musculus Q9WVS7 448 50086 S142 V V S D S L P S N S L K K S S
Rat Rattus norvegicus Q62862 448 50179 S142 V V S D S L P S N S L K K S S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516129 399 44778 K97 S L P G N S L K K S S A E L K
Chicken Gallus gallus NP_001073184 351 39168 E74 S L K K S S A E L K K I L A N
Frog Xenopus laevis NP_001084729 448 49926 S142 S V P D N I S S N C L K K S S
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 G84 A D D L E Q I G E L G R G A Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24324 396 43851 I112 R H T H T H L I M A R K L I H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10664 387 42776 L103 G V I M A R K L V H L E I K P
Sea Urchin Strong. purpuratus XP_786275 385 43129 V96 P L N I Y P Q V K P G G R K N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94A06 354 39192 G77 V I K V I G K G S S G N V Q L
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 Q215 A I I N T P K Q S L S A R R A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.3 99.5 63.3 N.A. 97.7 98.2 N.A. 82.3 74.1 84.8 30.5 N.A. 35 N.A. 37 49.3
Protein Similarity: 100 93.3 99.5 64.2 N.A. 99.1 99.1 N.A. 86.1 76.1 89.9 47.3 N.A. 54.2 N.A. 53.7 63.1
P-Site Identity: 100 100 100 0 N.A. 93.3 93.3 N.A. 6.6 6.6 60 6.6 N.A. 6.6 N.A. 13.3 0
P-Site Similarity: 100 100 100 6.6 N.A. 93.3 93.3 N.A. 33.3 33.3 80 20 N.A. 26.6 N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. 30.8 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 34 0 0 0 7 0 7 0 0 7 0 14 0 14 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 0 14 7 40 0 0 7 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 7 0 0 7 7 0 0 7 7 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 7 0 7 0 14 0 7 20 14 7 7 7 % G
% His: 0 7 0 7 0 7 0 0 0 7 7 0 0 0 7 % H
% Ile: 0 14 20 7 7 7 7 7 0 0 0 7 7 7 0 % I
% Lys: 0 0 14 7 0 0 20 7 14 7 7 47 40 14 7 % K
% Leu: 0 20 0 7 0 34 14 7 14 14 47 0 14 7 7 % L
% Met: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 7 7 14 0 0 0 40 0 0 7 7 0 14 % N
% Pro: 7 0 14 0 0 14 34 0 0 7 0 0 0 0 7 % P
% Gln: 7 0 0 0 0 7 7 7 0 0 0 0 0 7 0 % Q
% Arg: 7 0 0 7 0 14 0 0 0 0 7 7 14 7 0 % R
% Ser: 20 0 34 0 40 14 7 40 14 47 14 0 0 40 40 % S
% Thr: 0 0 7 0 14 0 0 7 0 0 0 0 0 0 0 % T
% Val: 20 47 0 7 0 0 0 7 7 0 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 14 0 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _