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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K5
All Species:
31.82
Human Site:
S276
Identified Species:
50
UniProt:
Q13163
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13163
NP_002748.1
448
50112
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Chimpanzee
Pan troglodytes
XP_001174798
467
51808
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Rhesus Macaque
Macaca mulatta
XP_001111645
449
50213
S277
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Dog
Lupus familis
XP_852868
288
32448
Q136
M
L
V
N
T
R
G
Q
V
K
L
C
D
F
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVS7
448
50086
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Rat
Rattus norvegicus
Q62862
448
50179
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516129
399
44778
S227
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Chicken
Gallus gallus
NP_001073184
351
39168
S199
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Frog
Xenopus laevis
NP_001084729
448
49926
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
P209
V
I
H
R
D
V
K
P
S
N
V
L
I
N
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
G244
S
M
A
N
S
F
V
G
T
R
S
Y
M
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
V229
D
S
M
A
N
S
F
V
G
T
R
S
Y
M
A
Sea Urchin
Strong. purpuratus
XP_786275
385
43129
I223
F
T
E
N
R
I
S
I
C
T
E
F
M
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A06
354
39192
G202
N
L
L
I
N
H
R
G
E
V
K
I
T
D
F
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
H479
L
K
E
L
K
E
Q
H
N
I
I
H
R
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
99.5
63.3
N.A.
97.7
98.2
N.A.
82.3
74.1
84.8
30.5
N.A.
35
N.A.
37
49.3
Protein Similarity:
100
93.3
99.5
64.2
N.A.
99.1
99.1
N.A.
86.1
76.1
89.9
47.3
N.A.
54.2
N.A.
53.7
63.1
P-Site Identity:
100
100
100
6.6
N.A.
100
100
N.A.
100
100
100
6.6
N.A.
0
N.A.
0
6.6
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
100
100
100
20
N.A.
6.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
47.5
42.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
0
0
0
0
0
0
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% C
% Asp:
7
0
0
0
7
0
0
0
0
0
0
0
7
20
60
% D
% Glu:
0
0
14
0
0
7
0
0
7
0
7
0
0
0
0
% E
% Phe:
7
0
0
0
0
7
7
0
0
0
0
7
0
7
7
% F
% Gly:
0
54
0
0
0
0
7
14
7
0
0
0
0
0
7
% G
% His:
0
0
7
0
0
7
0
7
0
0
0
7
54
0
0
% H
% Ile:
0
7
0
7
0
7
0
7
0
7
60
7
7
0
0
% I
% Lys:
54
7
0
0
7
0
7
0
0
60
7
0
0
0
0
% K
% Leu:
7
14
60
7
0
54
0
0
54
0
7
60
0
0
0
% L
% Met:
7
7
7
0
0
0
0
0
0
0
0
0
14
7
7
% M
% Asn:
7
0
0
20
14
0
0
0
7
7
0
0
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% P
% Gln:
0
0
0
0
0
0
7
7
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
7
7
7
7
0
0
7
7
0
7
54
0
% R
% Ser:
7
7
0
0
7
7
7
54
7
0
7
7
0
7
0
% S
% Thr:
0
7
0
54
7
0
0
0
7
14
0
0
7
0
0
% T
% Val:
7
0
7
0
0
7
7
7
7
7
7
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
54
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
54
0
0
0
0
0
0
7
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _