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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAP2K5 All Species: 23.33
Human Site: S365 Identified Species: 36.67
UniProt: Q13163 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13163 NP_002748.1 448 50112 S365 Q I Q K N Q G S L M P L Q L L
Chimpanzee Pan troglodytes XP_001174798 467 51808 I365 P L Q L L Q C I V D E D S P V
Rhesus Macaque Macaca mulatta XP_001111645 449 50213 S366 Q I Q K N Q G S L M P L Q L L
Dog Lupus familis XP_852868 288 32448 V225 E D S P V L P V G E F S E P F
Cat Felis silvestris
Mouse Mus musculus Q9WVS7 448 50086 S365 Q I Q K N Q G S L M P L Q L L
Rat Rattus norvegicus Q62862 448 50179 S365 Q I Q K N Q G S L M P L Q L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516129 399 44778 S316 Q I Q K N Q G S L M P L Q L L
Chicken Gallus gallus NP_001073184 351 39168 A288 Q E S P V L P A G E F S E P F
Frog Xenopus laevis NP_001084729 448 49926 S365 Q I Q K N H G S L M P L Q I L
Zebra Danio Brachydanio rerio Q9DGE0 361 40575 V298 F Q Q L K Q V V E E P S P Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24324 396 43851 F333 P K L E H K I F S T E F K D F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10664 387 42776 N318 E M L D Y I V N G P P P T L P
Sea Urchin Strong. purpuratus XP_786275 385 43129 L312 A T P R D Q E L S H P P R L P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94A06 354 39192 C291 I V E N P P P C A P S N L F S
Baker's Yeast Sacchar. cerevisiae P08018 668 72701 T568 R Y P Y P P E T Y D N I F S Q
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.3 99.5 63.3 N.A. 97.7 98.2 N.A. 82.3 74.1 84.8 30.5 N.A. 35 N.A. 37 49.3
Protein Similarity: 100 93.3 99.5 64.2 N.A. 99.1 99.1 N.A. 86.1 76.1 89.9 47.3 N.A. 54.2 N.A. 53.7 63.1
P-Site Identity: 100 13.3 100 0 N.A. 100 100 N.A. 100 6.6 86.6 26.6 N.A. 0 N.A. 13.3 20
P-Site Similarity: 100 33.3 100 13.3 N.A. 100 100 N.A. 100 20 93.3 26.6 N.A. 26.6 N.A. 33.3 40
Percent
Protein Identity: N.A. N.A. N.A. 30.8 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. 47.5 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 7 7 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 7 7 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 7 7 0 0 0 0 14 0 7 0 7 0 % D
% Glu: 14 7 7 7 0 0 14 0 7 20 14 0 14 0 0 % E
% Phe: 7 0 0 0 0 0 0 7 0 0 14 7 7 7 20 % F
% Gly: 0 0 0 0 0 0 40 0 20 0 0 0 0 0 0 % G
% His: 0 0 0 0 7 7 0 0 0 7 0 0 0 0 0 % H
% Ile: 7 40 0 0 0 7 7 7 0 0 0 7 0 7 0 % I
% Lys: 0 7 0 40 7 7 0 0 0 0 0 0 7 0 0 % K
% Leu: 0 7 14 14 7 14 0 7 40 0 0 40 7 47 47 % L
% Met: 0 7 0 0 0 0 0 0 0 40 0 0 0 0 0 % M
% Asn: 0 0 0 7 40 0 0 7 0 0 7 7 0 0 0 % N
% Pro: 14 0 14 14 14 14 20 0 0 14 60 14 7 20 14 % P
% Gln: 47 7 54 0 0 54 0 0 0 0 0 0 40 7 7 % Q
% Arg: 7 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % R
% Ser: 0 0 14 0 0 0 0 40 14 0 7 20 7 7 7 % S
% Thr: 0 7 0 0 0 0 0 7 0 7 0 0 7 0 0 % T
% Val: 0 7 0 0 14 0 14 14 7 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 7 7 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _