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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAPK7 All Species: 7.58
Human Site: S548 Identified Species: 12.82
UniProt: Q13164 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13164 NP_002740.2 816 88386 S548 K E R G A G A S G G P S T D P
Chimpanzee Pan troglodytes XP_511332 494 55249 N241 S N L L V N E N C E L K I G D
Rhesus Macaque Macaca mulatta XP_001099721 816 88521 S548 K E R G A G A S G G P S T D P
Dog Lupus familis XP_546651 731 80417 A478 I S D N T K A A L K A A L L K
Cat Felis silvestris
Mouse Mus musculus Q9WVS8 806 87714 Q536 K E R E K R R Q E R E R K E R
Rat Rattus norvegicus P0C865 806 87808 R534 R A K E R E K R R Q E R E R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518277 258 29416
Chicken Gallus gallus
Frog Xenopus laevis P26696 361 41238 Q108 M K D V Y I V Q D L M E T D L
Zebra Danio Brachydanio rerio NP_001013469 862 94944 E547 K K E G A I S E D T K A A L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780133 1079 118303 S712 R D R S N S S S Q K T I S E D
Poplar Tree Populus trichocarpa XP_002302599 372 42612 Y119 T E N F N D V Y I V Y E L M D
Maize Zea mays NP_001152745 397 44917 Y144 R E A F N D V Y I A Y E L M D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q39024 376 42833 V123 N F N D V Y I V Y E L M D T D
Baker's Yeast Sacchar. cerevisiae Q00772 484 55617 P231 A E F L G G K P I F K G K D Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 54.6 97.6 86.7 N.A. 92 92.1 N.A. 30.3 N.A. 24.1 47.3 N.A. N.A. N.A. N.A. 32.7
Protein Similarity: 100 54.6 98 87.9 N.A. 93.2 93.3 N.A. 31 N.A. 32.8 59.1 N.A. N.A. N.A. N.A. 46.7
P-Site Identity: 100 0 100 6.6 N.A. 20 0 N.A. 0 N.A. 13.3 20 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 6.6 100 20 N.A. 26.6 13.3 N.A. 0 N.A. 20 40 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: 26.2 26.1 N.A. 25.7 28.8 N.A.
Protein Similarity: 35 35 N.A. 34.6 40.5 N.A.
P-Site Identity: 6.6 6.6 N.A. 0 20 N.A.
P-Site Similarity: 6.6 13.3 N.A. 0 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 22 0 22 8 0 8 8 15 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % C
% Asp: 0 8 15 8 0 15 0 0 15 0 0 0 8 29 36 % D
% Glu: 0 43 8 15 0 8 8 8 8 15 15 22 8 15 0 % E
% Phe: 0 8 8 15 0 0 0 0 0 8 0 0 0 0 0 % F
% Gly: 0 0 0 22 8 22 0 0 15 15 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 15 8 0 22 0 0 8 8 0 0 % I
% Lys: 29 15 8 0 8 8 15 0 0 15 15 8 15 0 22 % K
% Leu: 0 0 8 15 0 0 0 0 8 8 15 0 22 15 8 % L
% Met: 8 0 0 0 0 0 0 0 0 0 8 8 0 15 0 % M
% Asn: 8 8 15 8 22 8 0 8 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 15 0 0 0 15 % P
% Gln: 0 0 0 0 0 0 0 15 8 8 0 0 0 0 0 % Q
% Arg: 22 0 29 0 8 8 8 8 8 8 0 15 0 8 8 % R
% Ser: 8 8 0 8 0 8 15 22 0 0 0 15 8 0 0 % S
% Thr: 8 0 0 0 8 0 0 0 0 8 8 0 22 8 0 % T
% Val: 0 0 0 8 15 0 22 8 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 8 0 15 8 0 15 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _