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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PAPPA All Species: 10.91
Human Site: S1297 Identified Species: 40
UniProt: Q13219 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13219 NP_002572.2 1627 180973 S1297 H H Q V Y A A S F S C P E G T
Chimpanzee Pan troglodytes XP_514020 1791 198653 N1476 P S L V N Y A N F S C S E G T
Rhesus Macaque Macaca mulatta XP_001095160 1573 175281 S1257 F D P V T L S S C Q R G E T Y
Dog Lupus familis XP_538813 1502 167461 C1189 G S K C S F Q C R H P A Q L K
Cat Felis silvestris
Mouse Mus musculus Q8R4K8 1624 181300 S1294 H H H V Y A A S F S C P E G T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415522 1603 178826 T1273 Q Y H V Y P A T F N C S E G T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795597 1601 177169 T1278 Q L D S S L A T A A C P T G T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 42.9 86.1 84.8 N.A. 91.2 N.A. N.A. N.A. 77.9 N.A. N.A. N.A. N.A. N.A. N.A. 36.3
Protein Similarity: 100 60.1 87.8 88.4 N.A. 95.7 N.A. N.A. N.A. 87 N.A. N.A. N.A. N.A. N.A. N.A. 53.1
P-Site Identity: 100 53.3 20 0 N.A. 93.3 N.A. N.A. N.A. 53.3 N.A. N.A. N.A. N.A. N.A. N.A. 33.3
P-Site Similarity: 100 60 26.6 13.3 N.A. 93.3 N.A. N.A. N.A. 73.3 N.A. N.A. N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 29 72 0 15 15 0 15 0 0 0 % A
% Cys: 0 0 0 15 0 0 0 15 15 0 72 0 0 0 0 % C
% Asp: 0 15 15 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 72 0 0 % E
% Phe: 15 0 0 0 0 15 0 0 58 0 0 0 0 0 0 % F
% Gly: 15 0 0 0 0 0 0 0 0 0 0 15 0 72 0 % G
% His: 29 29 29 0 0 0 0 0 0 15 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 15 0 0 0 0 0 0 0 0 0 0 0 15 % K
% Leu: 0 15 15 0 0 29 0 0 0 0 0 0 0 15 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 15 0 0 15 0 15 0 0 0 0 0 % N
% Pro: 15 0 15 0 0 15 0 0 0 0 15 43 0 0 0 % P
% Gln: 29 0 15 0 0 0 15 0 0 15 0 0 15 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 15 0 15 0 0 0 0 % R
% Ser: 0 29 0 15 29 0 15 43 0 43 0 29 0 0 0 % S
% Thr: 0 0 0 0 15 0 0 29 0 0 0 0 15 15 72 % T
% Val: 0 0 0 72 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 15 0 0 43 15 0 0 0 0 0 0 0 0 15 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _