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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRKG2 All Species: 35.15
Human Site: Y574 Identified Species: 70.3
UniProt: Q13237 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13237 NP_006250.1 762 87432 Y574 L H R L G I I Y R D L K P E N
Chimpanzee Pan troglodytes XP_517194 773 88573 T594 K F C V A C V T E A F D Y L H
Rhesus Macaque Macaca mulatta XP_001084948 865 99274 Y677 L H R L G I I Y R D L K P E N
Dog Lupus familis XP_544949 762 87274 Y574 L H R L G I I Y R D L K P E N
Cat Felis silvestris
Mouse Mus musculus Q61410 762 87066 Y574 L H L L G I I Y R D L K P E N
Rat Rattus norvegicus Q64595 762 87163 Y574 L H R L G I I Y R D L K P E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001085599 783 89666 Y595 L H Q I G V L Y R D L K P E N
Zebra Danio Brachydanio rerio NP_001098749 768 87435 Y580 L H N N G I I Y R D L K P E N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q03042 768 86740 Y580 L H A R G I I Y R D L K P E N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O76360 780 86723 Y591 L H R K N I V Y R D L K P E N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SL76 1094 121370 F903 I H K N E I L F R G S S P E L
Baker's Yeast Sacchar. cerevisiae P05986 398 45959 F230 G H I K I T D F G F A K Y V P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 87.7 96.7 N.A. 96 96.3 N.A. N.A. N.A. 70.7 69.5 N.A. 45.4 N.A. 45 N.A.
Protein Similarity: 100 93.2 87.9 98.6 N.A. 98.6 99.3 N.A. N.A. N.A. 82.7 83.8 N.A. 64.9 N.A. 64.2 N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 100 N.A. N.A. N.A. 73.3 86.6 N.A. 86.6 N.A. 80 N.A.
P-Site Similarity: 100 20 100 100 N.A. 93.3 100 N.A. N.A. N.A. 100 86.6 N.A. 86.6 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 22.6 22 N.A.
Protein Similarity: N.A. N.A. N.A. 38 35.7 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 60 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 0 9 0 0 0 0 9 9 0 0 0 0 % A
% Cys: 0 0 9 0 0 9 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 0 0 75 0 9 0 0 0 % D
% Glu: 0 0 0 0 9 0 0 0 9 0 0 0 0 84 0 % E
% Phe: 0 9 0 0 0 0 0 17 0 9 9 0 0 0 0 % F
% Gly: 9 0 0 0 67 0 0 0 9 9 0 0 0 0 0 % G
% His: 0 92 0 0 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 9 0 9 9 9 75 59 0 0 0 0 0 0 0 0 % I
% Lys: 9 0 9 17 0 0 0 0 0 0 0 84 0 0 0 % K
% Leu: 75 0 9 42 0 0 17 0 0 0 75 0 0 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 17 9 0 0 0 0 0 0 0 0 0 75 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 84 0 9 % P
% Gln: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 42 9 0 0 0 0 84 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % S
% Thr: 0 0 0 0 0 9 0 9 0 0 0 0 0 0 0 % T
% Val: 0 0 0 9 0 9 17 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 75 0 0 0 0 17 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _