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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MAD2L1 All Species: 30.91
Human Site: Y64 Identified Species: 45.33
UniProt: Q13257 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13257 NP_002349.1 205 23510 Y64 T D L E L I K Y L N N V V E Q
Chimpanzee Pan troglodytes XP_517581 196 22483 T57 G L T L L V T T D L E L I K Y
Rhesus Macaque Macaca mulatta XP_001084989 205 23614 Y64 T D L E L I K Y L N N V V E Q
Dog Lupus familis XP_533278 205 23552 Y64 T D P E L M K Y L N N V V E Q
Cat Felis silvestris
Mouse Mus musculus Q9Z1B5 205 23580 Y64 T D P E L I K Y L N N V V E Q
Rat Rattus norvegicus NP_001100064 205 23520 Y64 T D P E L I K Y L N N V V E Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513397 205 23385 Y64 T D P D L I N Y L N N V V E Q
Chicken Gallus gallus XP_420629 206 23693 Y65 T D P E L K N Y L N N V V E Q
Frog Xenopus laevis NP_001080741 203 23361 L64 D P A L K E Y L N K V T D Q L
Zebra Danio Brachydanio rerio NP_001017739 202 23158 T63 T K L K N Y L T N V I S Q L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001023563 203 23510 M64 E K K L Q A F M D P L L Q Q V
Sea Urchin Strong. purpuratus XP_001178696 206 23671 Y65 T D E E L K T Y L T S V M E Q
Poplar Tree Populus trichocarpa XP_002311730 207 23536 F64 Q D E G V R S F I S N L N A Q
Maize Zea mays Q9XFH3 208 23486 F64 Q D E G V K N F I A S L T S Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LU93 209 23713 F65 E D E S V K S F M S N L T S Q
Baker's Yeast Sacchar. cerevisiae P40958 196 22266 D57 T H D D E L K D Y I R K I L L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.6 97.5 97.5 N.A. 94.1 94.1 N.A. 93.6 86.8 80.4 74.1 N.A. N.A. N.A. 50.2 65
Protein Similarity: 100 95.6 97.5 98.5 N.A. 96 97 N.A. 97.5 92.2 89.2 86.8 N.A. N.A. N.A. 72.1 77.6
P-Site Identity: 100 6.6 100 86.6 N.A. 93.3 93.3 N.A. 80 80 0 13.3 N.A. N.A. N.A. 0 60
P-Site Similarity: 100 33.3 100 93.3 N.A. 93.3 93.3 N.A. 86.6 80 6.6 26.6 N.A. N.A. N.A. 13.3 73.3
Percent
Protein Identity: 46.8 43.7 N.A. 44 41.4 N.A.
Protein Similarity: 67.6 65.8 N.A. 65.5 59.5 N.A.
P-Site Identity: 20 13.3 N.A. 20 13.3 N.A.
P-Site Similarity: 53.3 46.6 N.A. 53.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 7 0 0 0 7 0 0 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 69 7 13 0 0 0 7 13 0 0 0 7 0 0 % D
% Glu: 13 0 25 44 7 7 0 0 0 0 7 0 0 50 0 % E
% Phe: 0 0 0 0 0 0 7 19 0 0 0 0 0 0 0 % F
% Gly: 7 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 32 0 0 13 7 7 0 13 0 0 % I
% Lys: 0 13 7 7 7 25 38 0 0 7 0 7 0 7 7 % K
% Leu: 0 7 19 19 57 7 7 7 50 7 7 32 0 13 13 % L
% Met: 0 0 0 0 0 7 0 7 7 0 0 0 7 0 0 % M
% Asn: 0 0 0 0 7 0 19 0 13 44 57 0 7 0 0 % N
% Pro: 0 7 32 0 0 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 13 0 0 0 7 0 0 0 0 0 0 0 13 13 69 % Q
% Arg: 0 0 0 0 0 7 0 0 0 0 7 0 0 0 0 % R
% Ser: 0 0 0 7 0 0 13 0 0 13 13 7 0 13 0 % S
% Thr: 63 0 7 0 0 0 13 13 0 7 0 7 13 0 0 % T
% Val: 0 0 0 0 19 7 0 0 0 7 7 50 44 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 7 7 50 7 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _