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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SKP2 All Species: 7.58
Human Site: T225 Identified Species: 16.67
UniProt: Q13309 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13309 NP_005974.2 424 47761 T225 L S D P I V N T L A K N S N L
Chimpanzee Pan troglodytes XP_001147537 379 42771 N184 H F S T L A K N S N L V R L N
Rhesus Macaque Macaca mulatta XP_001093834 422 47441 N223 L S D P I V N N L A Q N S N L
Dog Lupus familis XP_546346 749 81658 N550 L S D P I V N N L A Q N S N L
Cat Felis silvestris
Mouse Mus musculus Q9Z0Z3 424 47748 T225 L S D P I V K T L A Q N E N L
Rat Rattus norvegicus Q9QZH7 276 30442 V82 R D I E G R V V E N I S K R C
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001007983 443 49750 S246 L S D D I I K S I A K N P S L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001036659 499 55071 R280 L S M A S I T R S S L L T L L
Honey Bee Apis mellifera XP_395497 484 54314 V289 L S L E K C T V N R L C C K A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780472 456 51238 A238 D D P A N I Q A I L A R C H S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49286 360 39891 R166 T A L A H L T R F C R K L K I
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 89.3 91.9 52.3 N.A. 86.3 23.5 N.A. N.A. 64.1 N.A. N.A. N.A. 30 27.8 N.A. 31.3
Protein Similarity: 100 89.3 94.5 54.6 N.A. 92.9 36.7 N.A. N.A. 74.4 N.A. N.A. N.A. 50.9 50.6 N.A. 50
P-Site Identity: 100 0 86.6 86.6 N.A. 80 0 N.A. N.A. 53.3 N.A. N.A. N.A. 20 13.3 N.A. 0
P-Site Similarity: 100 6.6 93.3 93.3 N.A. 86.6 6.6 N.A. N.A. 80 N.A. N.A. N.A. 40 13.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 20 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 36 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 28 0 10 0 10 0 46 10 0 0 0 10 % A
% Cys: 0 0 0 0 0 10 0 0 0 10 0 10 19 0 10 % C
% Asp: 10 19 46 10 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 19 0 0 0 0 10 0 0 0 10 0 0 % E
% Phe: 0 10 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 10 0 46 28 0 0 19 0 10 0 0 0 10 % I
% Lys: 0 0 0 0 10 0 28 0 0 0 19 10 10 19 0 % K
% Leu: 64 0 19 0 10 10 0 0 37 10 28 10 10 19 55 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 28 28 10 19 0 46 0 37 10 % N
% Pro: 0 0 10 37 0 0 0 0 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 28 0 0 0 0 % Q
% Arg: 10 0 0 0 0 10 0 19 0 10 10 10 10 10 0 % R
% Ser: 0 64 10 0 10 0 0 10 19 10 0 10 28 10 10 % S
% Thr: 10 0 0 10 0 0 28 19 0 0 0 0 10 0 0 % T
% Val: 0 0 0 0 0 37 10 19 0 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _