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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5R2
All Species:
14.24
Human Site:
S278
Identified Species:
34.81
UniProt:
Q13319
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13319
NP_003927.1
367
38705
S278
S
Y
M
G
N
E
I
S
Y
P
L
K
P
F
L
Chimpanzee
Pan troglodytes
XP_516099
367
38658
S278
S
Y
M
G
N
E
I
S
Y
P
L
K
P
F
L
Rhesus Macaque
Macaca mulatta
XP_001113074
307
34072
L230
Q
A
V
L
L
T
C
L
Y
L
S
Y
S
Y
M
Dog
Lupus familis
XP_853120
458
47635
S366
S
Y
M
G
N
E
I
S
Y
P
L
K
P
F
L
Cat
Felis silvestris
Mouse
Mus musculus
O35926
369
38896
S278
S
Y
M
G
N
E
I
S
Y
P
L
K
P
F
L
Rat
Rattus norvegicus
P61810
307
34013
L230
Q
A
V
L
L
T
C
L
Y
L
S
Y
S
Y
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089375
320
35634
Y243
A
C
F
L
T
C
L
Y
L
A
Y
S
Y
M
G
Zebra Danio
Brachydanio rerio
NP_001017569
308
34577
L230
Q
A
T
F
L
T
C
L
Y
L
A
Y
S
Y
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q22695
356
39856
R273
R
D
V
L
P
D
E
R
H
L
I
H
T
L
E
Sea Urchin
Strong. purpuratus
XP_794538
375
41683
V295
D
L
L
S
G
D
A
V
V
K
N
E
S
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
49.5
77.2
N.A.
94.3
48.7
N.A.
N.A.
N.A.
58.3
55.5
N.A.
N.A.
N.A.
31.6
36.5
Protein Similarity:
100
99.7
59.1
77.7
N.A.
94.8
58.5
N.A.
N.A.
N.A.
64.5
64.8
N.A.
N.A.
N.A.
42.5
49.8
P-Site Identity:
100
100
6.6
100
N.A.
100
6.6
N.A.
N.A.
N.A.
0
6.6
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
26.6
100
N.A.
100
26.6
N.A.
N.A.
N.A.
13.3
20
N.A.
N.A.
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
30
0
0
0
0
10
0
0
10
10
0
0
0
0
% A
% Cys:
0
10
0
0
0
10
30
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
0
20
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
40
10
0
0
0
0
10
0
10
10
% E
% Phe:
0
0
10
10
0
0
0
0
0
0
0
0
0
40
0
% F
% Gly:
0
0
0
40
10
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
40
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
10
0
40
0
0
0
% K
% Leu:
0
10
10
40
30
0
10
30
10
40
40
0
0
10
50
% L
% Met:
0
0
40
0
0
0
0
0
0
0
0
0
0
10
30
% M
% Asn:
0
0
0
0
40
0
0
0
0
0
10
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
40
0
0
40
0
0
% P
% Gln:
30
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% R
% Ser:
40
0
0
10
0
0
0
40
0
0
20
10
40
0
0
% S
% Thr:
0
0
10
0
10
30
0
0
0
0
0
0
10
0
0
% T
% Val:
0
0
30
0
0
0
0
10
10
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
40
0
0
0
0
0
10
70
0
10
30
10
30
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _